Ubiquitin carboxyl-terminal hydrolase 7
Intermolecular
Cysteine 576 and cysteine 576
Cysteine 315 and cysteine 315 L
Intramolecular
Cysteine 121 and cysteine 132
Cysteine 478 and cysteine 488
Cysteine 896 and cysteine 925 L
Cysteine 576 and cysteine 702
Cysteine 917 and cysteine 961
Cysteine 702 and cysteine 721
4pyz A 576 B 576
A redox-regulated disulphide may form between two units of Ubiquitin carboxyl-terminal hydrolase 7 at cysteines 576 and 576.
Details
Redox score ?
79
PDB code
4pyz
Structure name
crystal structure of the first two ubl domains of deubiquitylase usp7
Structure deposition date
2014-03-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide A name
Ubiquitin carboxyl-terminal hydrolase 7
Peptide B name
Ubiquitin carboxyl-terminal hydrolase 7
Peptide A accession
Q93009
Peptide B accession
Q93009
Peptide A residue number
576
Peptide B residue number
576
Ligandability
6f5h A 315 B 315
A redox-regulated disulphide may form between two units of Ubiquitin carboxyl-terminal hydrolase 7 at cysteines 315 and 315. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
6f5h
Structure name
crystal structure of usp7 in complex with a 4-hydroxypiperidine based inhibitor
Structure deposition date
2017-12-01
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
90
Peptide A name
Ubiquitin carboxyl-terminal hydrolase 7
Peptide B name
Ubiquitin carboxyl-terminal hydrolase 7
Peptide A accession
Q93009
Peptide B accession
Q93009
Peptide A residue number
315
Peptide B residue number
315
Ligandability
3mqs C 121 C 132
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 7 between cysteines 121 and 132. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
3mqs
Structure name
crystal structure of the usp7:hdm2(psts) complex
Structure deposition date
2010-04-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
82
Peptide accession
Q93009
Residue number A
121
Residue number B
132
Peptide name
Ubiquitin carboxyl-terminal hydrolase 7
Ligandability
Cysteine 121 of Ubiquitin carboxyl-terminal hydrolase 7
Cysteine 132 of Ubiquitin carboxyl-terminal hydrolase 7
5jtj A 478 A 488
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 7 between cysteines 478 and 488. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
5jtj
Structure name
usp7cd-ctp in complex with ubiquitin
Structure deposition date
2016-05-09
Thiol separation (Å)
6
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
50
Peptide accession
Q93009
Residue number A
478
Residue number B
488
Peptide name
Ubiquitin carboxyl-terminal hydrolase 7
Ligandability
Cysteine 478 of Ubiquitin carboxyl-terminal hydrolase 7
Cysteine 488 of Ubiquitin carboxyl-terminal hydrolase 7
5jtv E 896 E 925
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 7 between cysteines 896 and 925. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
5jtv
Structure name
usp7cd-ubl45 in complex with ubiquitin
Structure deposition date
2016-05-09
Thiol separation (Å)
6
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
82
Peptide accession
Q93009
Residue number A
896
Residue number B
925
Peptide name
Ubiquitin carboxyl-terminal hydrolase 7
Ligandability
Cysteine 896 of Ubiquitin carboxyl-terminal hydrolase 7
Cysteine 925 of Ubiquitin carboxyl-terminal hydrolase 7
6p5l B 576 B 702
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 7 between cysteines 576 and 702. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
6p5l
Structure name
crystal structure of ubl123 with an ezh2 peptide
Structure deposition date
2019-05-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
42
Peptide accession
Q93009
Residue number A
576
Residue number B
702
Peptide name
Ubiquitin carboxyl-terminal hydrolase 7
Ligandability
Cysteine 576 of Ubiquitin carboxyl-terminal hydrolase 7
Cysteine 702 of Ubiquitin carboxyl-terminal hydrolase 7
7vij A 917 A 961
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 7 between cysteines 917 and 961. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7vij
Structure name
crystal structure of usp7-hubl domain
Structure deposition date
2021-09-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
2
Peptide accession
Q93009
Residue number A
917
Residue number B
961
Peptide name
Ubiquitin carboxyl-terminal hydrolase 7
Ligandability
Cysteine 917 of Ubiquitin carboxyl-terminal hydrolase 7
Cysteine 961 of Ubiquitin carboxyl-terminal hydrolase 7
6p5l B 702 B 721
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 7 between cysteines 702 and 721. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
6p5l
Structure name
crystal structure of ubl123 with an ezh2 peptide
Structure deposition date
2019-05-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
42
Peptide accession
Q93009
Residue number A
702
Residue number B
721
Peptide name
Ubiquitin carboxyl-terminal hydrolase 7
Ligandability
Cysteine 702 of Ubiquitin carboxyl-terminal hydrolase 7
Cysteine 721 of Ubiquitin carboxyl-terminal hydrolase 7
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