ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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N-alpha-acetyltransferase 80

Intramolecular
Cysteine 75 and cysteine 104
A redox-regulated disulphide may form within N-alpha-acetyltransferase 80 between cysteines 75 and 104 (97 and 126 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6nbe
Structure name
ternary complex of ac-alpha-actin with profilin and coa-naa80
Structure deposition date
2018-12-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
89
Minimum pKa ?
11
% buried
100
Peptide accession
Q93015
Residue number A
75
Residue number B
104
Peptide name
N-alpha-acetyltransferase 80

Ligandability

Cysteine 75 of N-alpha-acetyltransferase 80

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of N-alpha-acetyltransferase 80

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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