ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Exostosin-2

Intramolecular
Cysteine 96 and cysteine 151
Cysteine 85 and cysteine 90
Cysteine 626 and cysteine 676
Cysteine 318 and cysteine 339
A redox-regulated disulphide may form within Exostosin-2 between cysteines 96 and 151.

Details

Redox score ?
83
PDB code
7uqx
Structure name
cryo-em structure of the human exostosin-1 and exostosin-2 heterodimer in complex with udp-glcnac
Structure deposition date
2022-04-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q93063
Residue number A
96
Residue number B
151
Peptide name
Exostosin-2

Ligandability

Cysteine 96 of Exostosin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 151 of Exostosin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exostosin-2 between cysteines 85 and 90.

Details

Redox score ?
83
PDB code
7uqy
Structure name
cryo-em structure of the human exostosin-1 and exostosin-2 heterodimer in complex with udp-glca
Structure deposition date
2022-04-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q93063
Residue number A
85
Residue number B
90
Peptide name
Exostosin-2

Ligandability

Cysteine 85 of Exostosin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 90 of Exostosin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exostosin-2 between cysteines 626 and 676.

Details

Redox score ?
82
PDB code
7scj
Structure name
cryo-em structure of the human exostosin-1 and exostosin-2 heterodimer in complex with a 4-sugar oligosaccharide acceptor analog
Structure deposition date
2021-09-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q93063
Residue number A
626
Residue number B
676
Peptide name
Exostosin-2

Ligandability

Cysteine 626 of Exostosin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 676 of Exostosin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exostosin-2 between cysteines 318 and 339.

Details

Redox score ?
76
PDB code
7scj
Structure name
cryo-em structure of the human exostosin-1 and exostosin-2 heterodimer in complex with a 4-sugar oligosaccharide acceptor analog
Structure deposition date
2021-09-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
95
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q93063
Residue number A
318
Residue number B
339
Peptide name
Exostosin-2

Ligandability

Cysteine 318 of Exostosin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 339 of Exostosin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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