ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ribonuclease K6

Intramolecular
Cysteine 60 and cysteine 114
Cysteine 85 and cysteine 92
Cysteine 46 and cysteine 104
Cysteine 78 and cysteine 129
Cysteine 92 and cysteine 129
Cysteine 85 and cysteine 129
Cysteine 78 and cysteine 92
A redox-regulated disulphide may form within Ribonuclease K6 between cysteines 60 and 114 (37 and 91 respectively in this structure).

Details

Redox score ?
87
PDB code
6mv7
Structure name
crystal structure of rnase 6
Structure deposition date
2018-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q93091
Residue number A
60
Residue number B
114
Peptide name
Ribonuclease K6

Ligandability

Cysteine 60 of Ribonuclease K6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of Ribonuclease K6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease K6 between cysteines 85 and 92 (62 and 69 respectively in this structure).

Details

Redox score ?
86
PDB code
4x09
Structure name
structure of human rnase 6 in complex with sulphate anions
Structure deposition date
2014-11-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q93091
Residue number A
85
Residue number B
92
Peptide name
Ribonuclease K6

Ligandability

Cysteine 85 of Ribonuclease K6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 92 of Ribonuclease K6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease K6 between cysteines 46 and 104 (23 and 81 respectively in this structure).

Details

Redox score ?
86
PDB code
6enp
Structure name
atomic resolution structure of human rnase 6 in the presence of phosphate anions in p21 space group
Structure deposition date
2017-10-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q93091
Residue number A
46
Residue number B
104
Peptide name
Ribonuclease K6

Ligandability

Cysteine 46 of Ribonuclease K6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Ribonuclease K6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease K6 between cysteines 78 and 129 (55 and 106 respectively in this structure).

Details

Redox score ?
83
PDB code
4x09
Structure name
structure of human rnase 6 in complex with sulphate anions
Structure deposition date
2014-11-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q93091
Residue number A
78
Residue number B
129
Peptide name
Ribonuclease K6

Ligandability

Cysteine 78 of Ribonuclease K6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 129 of Ribonuclease K6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease K6 between cysteines 92 and 129 (69 and 106 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
5oab
Structure name
a novel crystal form of human rnase6 at atomic resolution
Structure deposition date
2017-06-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q93091
Residue number A
92
Residue number B
129
Peptide name
Ribonuclease K6

Ligandability

Cysteine 92 of Ribonuclease K6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 129 of Ribonuclease K6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease K6 between cysteines 85 and 129 (62 and 106 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
4x09
Structure name
structure of human rnase 6 in complex with sulphate anions
Structure deposition date
2014-11-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q93091
Residue number A
85
Residue number B
129
Peptide name
Ribonuclease K6

Ligandability

Cysteine 85 of Ribonuclease K6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 129 of Ribonuclease K6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease K6 between cysteines 78 and 92 (55 and 69 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6mv6
Structure name
crystal structure of rnase 6
Structure deposition date
2018-10-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q93091
Residue number A
78
Residue number B
92
Peptide name
Ribonuclease K6

Ligandability

Cysteine 78 of Ribonuclease K6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 92 of Ribonuclease K6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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