ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein tyrosine phosphatase type IVA 1

Intramolecular
Cysteine 49 and cysteine 104
Cysteine 98 and cysteine 99
A redox-regulated disulphide may form within Protein tyrosine phosphatase type IVA 1 between cysteines 49 and 104.

Details

Redox score ?
83
PDB code
3rz2
Structure name
crystal of prl-1 complexed with peptide
Structure deposition date
2011-05-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q78EG7
Residue number A
49
Residue number B
104
Peptide name
Protein tyrosine phosphatase type IVA 1

Ligandability

Cysteine 49 of Protein tyrosine phosphatase type IVA 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Protein tyrosine phosphatase type IVA 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein tyrosine phosphatase type IVA 1 between cysteines 98 and 99. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
1x24
Structure name
prl-1 (ptp4a)
Structure deposition date
2005-04-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
54
Peptide accession
Q78EG7
Residue number A
98
Residue number B
99
Peptide name
Protein tyrosine phosphatase type IVA 1

Ligandability

Cysteine 98 of Protein tyrosine phosphatase type IVA 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 99 of Protein tyrosine phosphatase type IVA 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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