ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Major histocompatibility complex class I-related gene protein

Intramolecular
Cysteine 120 and cysteine 183
Cysteine 222 and cysteine 278
A redox-regulated disulphide may form within Major histocompatibility complex class I-related gene protein between cysteines 120 and 183 (98 and 161 respectively in this structure).

Details

Redox score ?
76
PDB code
5d7l
Structure name
structure of human mr1-5-op-ru in complex with human mav36 tcr
Structure deposition date
2015-08-14
Thiol separation (Å)
3
Half-sphere exposure sum ?
69
Minimum pKa ?
8
% buried
84
Peptide accession
Q95460
Residue number A
120
Residue number B
183
Peptide name
Major histocompatibility complex class I-related gene protein

Ligandability

Cysteine 120 of Major histocompatibility complex class I-related gene protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of Major histocompatibility complex class I-related gene protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Major histocompatibility complex class I-related gene protein between cysteines 222 and 278 (200 and 256 respectively in this structure).

Details

Redox score ?
76
PDB code
5d7l
Structure name
structure of human mr1-5-op-ru in complex with human mav36 tcr
Structure deposition date
2015-08-14
Thiol separation (Å)
3
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
40
Peptide accession
Q95460
Residue number A
222
Residue number B
278
Peptide name
Major histocompatibility complex class I-related gene protein

Ligandability

Cysteine 222 of Major histocompatibility complex class I-related gene protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 278 of Major histocompatibility complex class I-related gene protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: