ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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MHC class I antigen

Intramolecular
Cysteine 125 and cysteine 189
Cysteine 228 and cysteine 284
A redox-regulated disulphide may form within MHC class I antigen between cysteines 125 and 189 (104 and 168 respectively in this structure).

Details

Redox score ?
83
PDB code
7edo
Structure name
first insight into marsupial mhc i peptide presentation: immune features of lower mammals paralleled with bats
Structure deposition date
2021-03-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q95IT0
Residue number A
125
Residue number B
189
Peptide name
MHC class I antigen

Ligandability

Cysteine 125 of MHC class I antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 189 of MHC class I antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class I antigen between cysteines 228 and 284 (207 and 263 respectively in this structure).

Details

Redox score ?
80
PDB code
7edo
Structure name
first insight into marsupial mhc i peptide presentation: immune features of lower mammals paralleled with bats
Structure deposition date
2021-03-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q95IT0
Residue number A
228
Residue number B
284
Peptide name
MHC class I antigen

Ligandability

Cysteine 228 of MHC class I antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 284 of MHC class I antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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