ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Pancreatic lipase-related protein type 2

Intramolecular
Cysteine 436 and cysteine 452
Cysteine 239 and cysteine 263
Cysteine 287 and cysteine 298
Cysteine 4 and cysteine 10
Cysteine 301 and cysteine 306
Cysteine 92 and cysteine 103
A redox-regulated disulphide may form within Pancreatic lipase-related protein type 2 between cysteines 436 and 452.

Details

Redox score ?
86
PDB code
1w52
Structure name
crystal structure of a proteolyzed form of pancreatic lipase related protein 2 from horse
Structure deposition date
2004-08-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q95KP4
Residue number A
436
Residue number B
452
Peptide name
Pancreatic lipase-related protein type 2

Ligandability

Cysteine 436 of Pancreatic lipase-related protein type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 452 of Pancreatic lipase-related protein type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pancreatic lipase-related protein type 2 between cysteines 239 and 263.

Details

Redox score ?
85
PDB code
1w52
Structure name
crystal structure of a proteolyzed form of pancreatic lipase related protein 2 from horse
Structure deposition date
2004-08-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q95KP4
Residue number A
239
Residue number B
263
Peptide name
Pancreatic lipase-related protein type 2

Ligandability

Cysteine 239 of Pancreatic lipase-related protein type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 263 of Pancreatic lipase-related protein type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pancreatic lipase-related protein type 2 between cysteines 287 and 298.

Details

Redox score ?
85
PDB code
1w52
Structure name
crystal structure of a proteolyzed form of pancreatic lipase related protein 2 from horse
Structure deposition date
2004-08-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q95KP4
Residue number A
287
Residue number B
298
Peptide name
Pancreatic lipase-related protein type 2

Ligandability

Cysteine 287 of Pancreatic lipase-related protein type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 298 of Pancreatic lipase-related protein type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pancreatic lipase-related protein type 2 between cysteines 4 and 10.

Details

Redox score ?
84
PDB code
1w52
Structure name
crystal structure of a proteolyzed form of pancreatic lipase related protein 2 from horse
Structure deposition date
2004-08-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
39
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q95KP4
Residue number A
4
Residue number B
10
Peptide name
Pancreatic lipase-related protein type 2

Ligandability

Cysteine 4 of Pancreatic lipase-related protein type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 10 of Pancreatic lipase-related protein type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pancreatic lipase-related protein type 2 between cysteines 301 and 306.

Details

Redox score ?
84
PDB code
1w52
Structure name
crystal structure of a proteolyzed form of pancreatic lipase related protein 2 from horse
Structure deposition date
2004-08-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q95KP4
Residue number A
301
Residue number B
306
Peptide name
Pancreatic lipase-related protein type 2

Ligandability

Cysteine 301 of Pancreatic lipase-related protein type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 306 of Pancreatic lipase-related protein type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pancreatic lipase-related protein type 2 between cysteines 92 and 103.

Details

Redox score ?
79
PDB code
1w52
Structure name
crystal structure of a proteolyzed form of pancreatic lipase related protein 2 from horse
Structure deposition date
2004-08-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q95KP4
Residue number A
92
Residue number B
103
Peptide name
Pancreatic lipase-related protein type 2

Ligandability

Cysteine 92 of Pancreatic lipase-related protein type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 103 of Pancreatic lipase-related protein type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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