ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mannose-6-phosphate/insulin-like growth factor II receptor

Intramolecular
Cysteine 1576 and cysteine 1612
Cysteine 1494 and cysteine 1531
Cysteine 1537 and cysteine 1544
Cysteine 1592 and cysteine 1624
A redox-regulated disulphide may form within Mannose-6-phosphate/insulin-like growth factor II receptor between cysteines 1576 and 1612.

Details

Redox score ?
86
PDB code
2lla
Structure name
nmr solution structure ensemble of domain 11 of the echidna m6p/igf2r receptor
Structure deposition date
2011-11-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q95LC7
Residue number A
1576
Residue number B
1612
Peptide name
Mannose-6-phosphate/insulin-like growth factor II receptor

Ligandability

Cysteine 1576 of Mannose-6-phosphate/insulin-like growth factor II receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1612 of Mannose-6-phosphate/insulin-like growth factor II receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mannose-6-phosphate/insulin-like growth factor II receptor between cysteines 1494 and 1531.

Details

Redox score ?
83
PDB code
2lla
Structure name
nmr solution structure ensemble of domain 11 of the echidna m6p/igf2r receptor
Structure deposition date
2011-11-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q95LC7
Residue number A
1494
Residue number B
1531
Peptide name
Mannose-6-phosphate/insulin-like growth factor II receptor

Ligandability

Cysteine 1494 of Mannose-6-phosphate/insulin-like growth factor II receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1531 of Mannose-6-phosphate/insulin-like growth factor II receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mannose-6-phosphate/insulin-like growth factor II receptor between cysteines 1537 and 1544.

Details

Redox score ?
82
PDB code
2lla
Structure name
nmr solution structure ensemble of domain 11 of the echidna m6p/igf2r receptor
Structure deposition date
2011-11-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q95LC7
Residue number A
1537
Residue number B
1544
Peptide name
Mannose-6-phosphate/insulin-like growth factor II receptor

Ligandability

Cysteine 1537 of Mannose-6-phosphate/insulin-like growth factor II receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1544 of Mannose-6-phosphate/insulin-like growth factor II receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mannose-6-phosphate/insulin-like growth factor II receptor between cysteines 1592 and 1624.

Details

Redox score ?
80
PDB code
2lla
Structure name
nmr solution structure ensemble of domain 11 of the echidna m6p/igf2r receptor
Structure deposition date
2011-11-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q95LC7
Residue number A
1592
Residue number B
1624
Peptide name
Mannose-6-phosphate/insulin-like growth factor II receptor

Ligandability

Cysteine 1592 of Mannose-6-phosphate/insulin-like growth factor II receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1624 of Mannose-6-phosphate/insulin-like growth factor II receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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