ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Liver-expressed antimicrobial peptide 2

Intramolecular
Cysteine 54 and cysteine 65
Cysteine 60 and cysteine 70
Cysteine 54 and cysteine 60
Cysteine 54 and cysteine 70
Cysteine 60 and cysteine 65
Cysteine 65 and cysteine 70
A redox-regulated disulphide may form within Liver-expressed antimicrobial peptide 2 between cysteines 54 and 65 (17 and 28 respectively in this structure).

Details

Redox score ?
87
PDB code
2l1q
Structure name
solution structure of human liver expressed antimicrobial peptide 2
Structure deposition date
2010-08-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q969E1
Residue number A
54
Residue number B
65
Peptide name
Liver-expressed antimicrobial peptide 2

Ligandability

Cysteine 54 of Liver-expressed antimicrobial peptide 2

Cysteine 65 of Liver-expressed antimicrobial peptide 2

A redox-regulated disulphide may form within Liver-expressed antimicrobial peptide 2 between cysteines 60 and 70 (23 and 33 respectively in this structure).

Details

Redox score ?
87
PDB code
2l1q
Structure name
solution structure of human liver expressed antimicrobial peptide 2
Structure deposition date
2010-08-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q969E1
Residue number A
60
Residue number B
70
Peptide name
Liver-expressed antimicrobial peptide 2

Ligandability

Cysteine 60 of Liver-expressed antimicrobial peptide 2

Cysteine 70 of Liver-expressed antimicrobial peptide 2

A redox-regulated disulphide may form within Liver-expressed antimicrobial peptide 2 between cysteines 54 and 60 (17 and 23 respectively in this structure).

Details

Redox score ?
82
PDB code
2l1q
Structure name
solution structure of human liver expressed antimicrobial peptide 2
Structure deposition date
2010-08-03
Thiol separation (Å)
3
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q969E1
Residue number A
54
Residue number B
60
Peptide name
Liver-expressed antimicrobial peptide 2

Ligandability

Cysteine 54 of Liver-expressed antimicrobial peptide 2

Cysteine 60 of Liver-expressed antimicrobial peptide 2

A redox-regulated disulphide may form within Liver-expressed antimicrobial peptide 2 between cysteines 54 and 70 (17 and 33 respectively in this structure).

Details

Redox score ?
75
PDB code
2l1q
Structure name
solution structure of human liver expressed antimicrobial peptide 2
Structure deposition date
2010-08-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q969E1
Residue number A
54
Residue number B
70
Peptide name
Liver-expressed antimicrobial peptide 2

Ligandability

Cysteine 54 of Liver-expressed antimicrobial peptide 2

Cysteine 70 of Liver-expressed antimicrobial peptide 2

A redox-regulated disulphide may form within Liver-expressed antimicrobial peptide 2 between cysteines 60 and 65 (23 and 28 respectively in this structure).

Details

Redox score ?
68
PDB code
2l1q
Structure name
solution structure of human liver expressed antimicrobial peptide 2
Structure deposition date
2010-08-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q969E1
Residue number A
60
Residue number B
65
Peptide name
Liver-expressed antimicrobial peptide 2

Ligandability

Cysteine 60 of Liver-expressed antimicrobial peptide 2

Cysteine 65 of Liver-expressed antimicrobial peptide 2

A redox-regulated disulphide may form within Liver-expressed antimicrobial peptide 2 between cysteines 65 and 70 (28 and 33 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
2l1q
Structure name
solution structure of human liver expressed antimicrobial peptide 2
Structure deposition date
2010-08-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q969E1
Residue number A
65
Residue number B
70
Peptide name
Liver-expressed antimicrobial peptide 2

Ligandability

Cysteine 65 of Liver-expressed antimicrobial peptide 2

Cysteine 70 of Liver-expressed antimicrobial peptide 2

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