ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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F-box/WD repeat-containing protein 7

Intramolecular
Cysteine 466 and cysteine 506
Cysteine 629 and cysteine 684
A redox-regulated disulphide may form within F-box/WD repeat-containing protein 7 between cysteines 466 and 506 (2466 and 2506 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2ovp
Structure name
structure of the skp1-fbw7 complex
Structure deposition date
2007-02-14
Thiol separation (Å)
6
Half-sphere exposure sum ?
101
Minimum pKa ?
12
% buried
100
Peptide accession
Q969H0
Residue number A
466
Residue number B
506
Peptide name
F-box/WD repeat-containing protein 7

Ligandability

Cysteine 466 of F-box/WD repeat-containing protein 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 506 of F-box/WD repeat-containing protein 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within F-box/WD repeat-containing protein 7 between cysteines 629 and 684 (2629 and 2684 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
2ovp
Structure name
structure of the skp1-fbw7 complex
Structure deposition date
2007-02-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
101
Minimum pKa ?
10
% buried
100
Peptide accession
Q969H0
Residue number A
629
Residue number B
684
Peptide name
F-box/WD repeat-containing protein 7

Ligandability

Cysteine 629 of F-box/WD repeat-containing protein 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 684 of F-box/WD repeat-containing protein 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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