ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ribonuclease P/MRP protein subunit POP5

Intermolecular
Cysteine 146 and cysteine 66 of Ribonuclease P protein subunit p20 L
Intramolecular
Cysteine 20 and cysteine 96
Cysteine 49 and cysteine 69
Cysteine 11 and cysteine 69
A redox-regulated disulphide may form between cysteine 146 of Ribonuclease P/MRP protein subunit POP5 and cysteine 66 of Ribonuclease P protein subunit p20. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
6ahr
Structure name
cryo-em structure of human ribonuclease p
Structure deposition date
2018-08-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
54
Peptide A name
Ribonuclease P/MRP protein subunit POP5
Peptide B name
Ribonuclease P protein subunit p20
Peptide A accession
Q969H6
Peptide B accession
O75817
Peptide A residue number
146
Peptide B residue number
66

Ligandability

Cysteine 146 of Ribonuclease P/MRP protein subunit POP5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of Ribonuclease P protein subunit p20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease P/MRP protein subunit POP5 between cysteines 20 and 96. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6ahr
Structure name
cryo-em structure of human ribonuclease p
Structure deposition date
2018-08-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
9
% buried
61
Peptide accession
Q969H6
Residue number A
20
Residue number B
96
Peptide name
Ribonuclease P/MRP protein subunit POP5

Ligandability

Cysteine 20 of Ribonuclease P/MRP protein subunit POP5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of Ribonuclease P/MRP protein subunit POP5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease P/MRP protein subunit POP5 between cysteines 49 and 69. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6ahu
Structure name
cryo-em structure of human ribonuclease p with mature trna
Structure deposition date
2018-08-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
100
Peptide accession
Q969H6
Residue number A
49
Residue number B
69
Peptide name
Ribonuclease P/MRP protein subunit POP5

Ligandability

Cysteine 49 of Ribonuclease P/MRP protein subunit POP5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 69 of Ribonuclease P/MRP protein subunit POP5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease P/MRP protein subunit POP5 between cysteines 11 and 69. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
6ahu
Structure name
cryo-em structure of human ribonuclease p with mature trna
Structure deposition date
2018-08-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
100
Peptide accession
Q969H6
Residue number A
11
Residue number B
69
Peptide name
Ribonuclease P/MRP protein subunit POP5

Ligandability

Cysteine 11 of Ribonuclease P/MRP protein subunit POP5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 69 of Ribonuclease P/MRP protein subunit POP5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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