ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

NEDD8-conjugating enzyme UBE2F

Intramolecular
Cysteine 50 and cysteine 52
A redox-regulated disulphide may form within NEDD8-conjugating enzyme UBE2F between cysteines 50 and 52. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
3fn1
Structure name
e2-ring expansion of the nedd8 cascade confers specificity to cullin modification
Structure deposition date
2008-12-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
33
Peptide accession
Q969M7
Residue number A
50
Residue number B
52
Peptide name
NEDD8-conjugating enzyme UBE2F

Ligandability

Cysteine 50 of NEDD8-conjugating enzyme UBE2F

Cysteine 52 of NEDD8-conjugating enzyme UBE2F

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