ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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GPI transamidase component PIG-T

Intermolecular
Cysteine 182 and cysteine 92 of GPI-anchor transamidase
Intramolecular
Cysteine 226 and cysteine 231
Cysteine 195 and cysteine 272
Cysteine 530 and cysteine 533
A redox-regulated disulphide may form between cysteine 182 of GPI transamidase component PIG-T and cysteine 92 of GPI-anchor transamidase.

Details

Redox score ?
79
PDB code
7w72
Structure name
structure of a human glycosylphosphatidylinositol (gpi) transamidase
Structure deposition date
2021-12-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide A name
GPI transamidase component PIG-T
Peptide B name
GPI-anchor transamidase
Peptide A accession
Q969N2
Peptide B accession
Q92643
Peptide A residue number
182
Peptide B residue number
92

Ligandability

Cysteine 182 of GPI transamidase component PIG-T

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 92 of GPI-anchor transamidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GPI transamidase component PIG-T between cysteines 226 and 231.

Details

Redox score ?
87
PDB code
7wld
Structure name
cryo-em structure of the human glycosylphosphatidylinositol transamidase complex at 2
Structure deposition date
2022-01-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q969N2
Residue number A
226
Residue number B
231
Peptide name
GPI transamidase component PIG-T

Ligandability

Cysteine 226 of GPI transamidase component PIG-T

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 231 of GPI transamidase component PIG-T

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GPI transamidase component PIG-T between cysteines 195 and 272.

Details

Redox score ?
82
PDB code
7w72
Structure name
structure of a human glycosylphosphatidylinositol (gpi) transamidase
Structure deposition date
2021-12-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q969N2
Residue number A
195
Residue number B
272
Peptide name
GPI transamidase component PIG-T

Ligandability

Cysteine 195 of GPI transamidase component PIG-T

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 272 of GPI transamidase component PIG-T

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GPI transamidase component PIG-T between cysteines 530 and 533. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
7w72
Structure name
structure of a human glycosylphosphatidylinositol (gpi) transamidase
Structure deposition date
2021-12-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
70
Peptide accession
Q969N2
Residue number A
530
Residue number B
533
Peptide name
GPI transamidase component PIG-T

Ligandability

Cysteine 530 of GPI transamidase component PIG-T

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 533 of GPI transamidase component PIG-T

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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