E3 ubiquitin-protein ligase TRIM63
Intramolecular
Cysteine 122 and cysteine 145
Cysteine 134 and cysteine 154
Cysteine 122 and cysteine 142
Cysteine 134 and cysteine 137
Cysteine 137 and cysteine 154
Cysteine 142 and cysteine 145
Cysteine 122 and cysteine 134
Cysteine 122 and cysteine 137
Cysteine 134 and cysteine 145
Cysteine 137 and cysteine 145
Cysteine 145 and cysteine 154
3ddt C 6 C 29
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase TRIM63 between cysteines 122 and 145 (6 and 29 respectively in this structure).
Details
Redox score ?
86
PDB code
3ddt
Structure name
crystal structure of the b2 box from murf1 in dimeric state
Structure deposition date
2008-06-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
6
% buried
22
Peptide accession
Q969Q1
Residue number A
122
Residue number B
145
Peptide name
E3 ubiquitin-protein ligase TRIM63
Ligandability
Cysteine 122 of E3 ubiquitin-protein ligase TRIM63
Cysteine 145 of E3 ubiquitin-protein ligase TRIM63
3ddt B 18 B 38
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase TRIM63 between cysteines 134 and 154 (18 and 38 respectively in this structure).
Details
Redox score ?
85
PDB code
3ddt
Structure name
crystal structure of the b2 box from murf1 in dimeric state
Structure deposition date
2008-06-06
Thiol separation (Å)
3
Half-sphere exposure sum ?
54
Minimum pKa ?
7
% buried
10
Peptide accession
Q969Q1
Residue number A
134
Residue number B
154
Peptide name
E3 ubiquitin-protein ligase TRIM63
Ligandability
Cysteine 134 of E3 ubiquitin-protein ligase TRIM63
Cysteine 154 of E3 ubiquitin-protein ligase TRIM63
3ddt C 6 C 26
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase TRIM63 between cysteines 122 and 142 (6 and 26 respectively in this structure).
Details
Redox score ?
84
PDB code
3ddt
Structure name
crystal structure of the b2 box from murf1 in dimeric state
Structure deposition date
2008-06-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
6
% buried
11
Peptide accession
Q969Q1
Residue number A
122
Residue number B
142
Peptide name
E3 ubiquitin-protein ligase TRIM63
Ligandability
Cysteine 122 of E3 ubiquitin-protein ligase TRIM63
Cysteine 142 of E3 ubiquitin-protein ligase TRIM63
3ddt C 18 C 21
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase TRIM63 between cysteines 134 and 137 (18 and 21 respectively in this structure).
Details
Redox score ?
84
PDB code
3ddt
Structure name
crystal structure of the b2 box from murf1 in dimeric state
Structure deposition date
2008-06-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
7
% buried
14
Peptide accession
Q969Q1
Residue number A
134
Residue number B
137
Peptide name
E3 ubiquitin-protein ligase TRIM63
Ligandability
Cysteine 134 of E3 ubiquitin-protein ligase TRIM63
Cysteine 137 of E3 ubiquitin-protein ligase TRIM63
3ddt B 21 B 38
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase TRIM63 between cysteines 137 and 154 (21 and 38 respectively in this structure).
Details
Redox score ?
76
PDB code
3ddt
Structure name
crystal structure of the b2 box from murf1 in dimeric state
Structure deposition date
2008-06-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
9
% buried
7
Peptide accession
Q969Q1
Residue number A
137
Residue number B
154
Peptide name
E3 ubiquitin-protein ligase TRIM63
Ligandability
Cysteine 137 of E3 ubiquitin-protein ligase TRIM63
Cysteine 154 of E3 ubiquitin-protein ligase TRIM63
3ddt A 26 A 29
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase TRIM63 between cysteines 142 and 145 (26 and 29 respectively in this structure).
Details
Redox score ?
69
PDB code
3ddt
Structure name
crystal structure of the b2 box from murf1 in dimeric state
Structure deposition date
2008-06-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
9
% buried
48
Peptide accession
Q969Q1
Residue number A
142
Residue number B
145
Peptide name
E3 ubiquitin-protein ligase TRIM63
Ligandability
Cysteine 142 of E3 ubiquitin-protein ligase TRIM63
Cysteine 145 of E3 ubiquitin-protein ligase TRIM63
2d8u A 11 A 23
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase TRIM63 between cysteines 122 and 134 (11 and 23 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
2d8u
Structure name
solution structure of the b-box domain of the human tripartite motif- containing 63 protein
Structure deposition date
2005-12-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
5
% buried
7
Peptide accession
Q969Q1
Residue number A
122
Residue number B
134
Peptide name
E3 ubiquitin-protein ligase TRIM63
Ligandability
Cysteine 122 of E3 ubiquitin-protein ligase TRIM63
Cysteine 134 of E3 ubiquitin-protein ligase TRIM63
2d8u A 11 A 26
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase TRIM63 between cysteines 122 and 137 (11 and 26 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
2d8u
Structure name
solution structure of the b-box domain of the human tripartite motif- containing 63 protein
Structure deposition date
2005-12-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
41
Minimum pKa ?
5
% buried
2
Peptide accession
Q969Q1
Residue number A
122
Residue number B
137
Peptide name
E3 ubiquitin-protein ligase TRIM63
Ligandability
Cysteine 122 of E3 ubiquitin-protein ligase TRIM63
Cysteine 137 of E3 ubiquitin-protein ligase TRIM63
3ddt C 18 C 29
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase TRIM63 between cysteines 134 and 145 (18 and 29 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
3ddt
Structure name
crystal structure of the b2 box from murf1 in dimeric state
Structure deposition date
2008-06-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
7
% buried
16
Peptide accession
Q969Q1
Residue number A
134
Residue number B
145
Peptide name
E3 ubiquitin-protein ligase TRIM63
Ligandability
Cysteine 134 of E3 ubiquitin-protein ligase TRIM63
Cysteine 145 of E3 ubiquitin-protein ligase TRIM63
2d8u A 26 A 34
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase TRIM63 between cysteines 137 and 145 (26 and 34 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
2d8u
Structure name
solution structure of the b-box domain of the human tripartite motif- containing 63 protein
Structure deposition date
2005-12-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
0
Peptide accession
Q969Q1
Residue number A
137
Residue number B
145
Peptide name
E3 ubiquitin-protein ligase TRIM63
Ligandability
Cysteine 137 of E3 ubiquitin-protein ligase TRIM63
Cysteine 145 of E3 ubiquitin-protein ligase TRIM63
3ddt B 29 B 38
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase TRIM63 between cysteines 145 and 154 (29 and 38 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
3ddt
Structure name
crystal structure of the b2 box from murf1 in dimeric state
Structure deposition date
2008-06-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
9
% buried
23
Peptide accession
Q969Q1
Residue number A
145
Residue number B
154
Peptide name
E3 ubiquitin-protein ligase TRIM63
Ligandability
Cysteine 145 of E3 ubiquitin-protein ligase TRIM63
Cysteine 154 of E3 ubiquitin-protein ligase TRIM63
If this tool was useful for finding a disulphide, please cite: