ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Lethal(3)malignant brain tumor-like protein 2

Intermolecular
Cysteine 531 and cysteine 531
Intramolecular
Cysteine 90 and cysteine 114
Cysteine 90 and cysteine 110
Cysteine 90 and cysteine 93
Cysteine 93 and cysteine 114
Cysteine 110 and cysteine 114
Cysteine 93 and cysteine 110
Cysteine 451 and cysteine 462
Cysteine 531 and cysteine 583
Cysteine 197 and cysteine 583
More...
Cysteine 446 and cysteine 490
Cysteine 554 and cysteine 594
A redox-regulated disulphide may form between two units of Lethal(3)malignant brain tumor-like protein 2 at cysteines 531 and 531. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
3f70
Structure name
crystal structure of l3mbtl2-h4k20me1 complex
Structure deposition date
2008-11-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
36
Peptide A name
Lethal(3)malignant brain tumor-like protein 2
Peptide B name
Lethal(3)malignant brain tumor-like protein 2
Peptide A accession
Q969R5
Peptide B accession
Q969R5
Peptide A residue number
531
Peptide B residue number
531

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lethal(3)malignant brain tumor-like protein 2 between cysteines 90 and 114.

Details

Redox score ?
89
PDB code
2w0t
Structure name
solution structure of the fcs zinc finger domain of human lmbl2
Structure deposition date
2008-10-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
5
% buried
0
Peptide accession
Q969R5
Residue number A
90
Residue number B
114
Peptide name
Lethal(3)malignant brain tumor-like protein 2

Ligandability

Cysteine 90 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lethal(3)malignant brain tumor-like protein 2 between cysteines 90 and 110.

Details

Redox score ?
89
PDB code
2w0t
Structure name
solution structure of the fcs zinc finger domain of human lmbl2
Structure deposition date
2008-10-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
5
% buried
0
Peptide accession
Q969R5
Residue number A
90
Residue number B
110
Peptide name
Lethal(3)malignant brain tumor-like protein 2

Ligandability

Cysteine 90 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lethal(3)malignant brain tumor-like protein 2 between cysteines 90 and 93.

Details

Redox score ?
88
PDB code
2w0t
Structure name
solution structure of the fcs zinc finger domain of human lmbl2
Structure deposition date
2008-10-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
5
% buried
0
Peptide accession
Q969R5
Residue number A
90
Residue number B
93
Peptide name
Lethal(3)malignant brain tumor-like protein 2

Ligandability

Cysteine 90 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lethal(3)malignant brain tumor-like protein 2 between cysteines 93 and 114.

Details

Redox score ?
80
PDB code
2w0t
Structure name
solution structure of the fcs zinc finger domain of human lmbl2
Structure deposition date
2008-10-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
0
Peptide accession
Q969R5
Residue number A
93
Residue number B
114
Peptide name
Lethal(3)malignant brain tumor-like protein 2

Ligandability

Cysteine 93 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lethal(3)malignant brain tumor-like protein 2 between cysteines 110 and 114.

Details

Redox score ?
77
PDB code
2w0t
Structure name
solution structure of the fcs zinc finger domain of human lmbl2
Structure deposition date
2008-10-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
9
% buried
0
Peptide accession
Q969R5
Residue number A
110
Residue number B
114
Peptide name
Lethal(3)malignant brain tumor-like protein 2

Ligandability

Cysteine 110 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lethal(3)malignant brain tumor-like protein 2 between cysteines 93 and 110.

Details

Redox score ?
74
PDB code
2w0t
Structure name
solution structure of the fcs zinc finger domain of human lmbl2
Structure deposition date
2008-10-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
10
% buried
0
Peptide accession
Q969R5
Residue number A
93
Residue number B
110
Peptide name
Lethal(3)malignant brain tumor-like protein 2

Ligandability

Cysteine 93 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lethal(3)malignant brain tumor-like protein 2 between cysteines 451 and 462.

Details

Redox score ?
70
PDB code
3f70
Structure name
crystal structure of l3mbtl2-h4k20me1 complex
Structure deposition date
2008-11-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
36
Peptide accession
Q969R5
Residue number A
451
Residue number B
462
Peptide name
Lethal(3)malignant brain tumor-like protein 2

Ligandability

Cysteine 451 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 462 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lethal(3)malignant brain tumor-like protein 2 between cysteines 531 and 583. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
3cey
Structure name
crystal structure of l3mbtl2
Structure deposition date
2008-02-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
44
Peptide accession
Q969R5
Residue number A
531
Residue number B
583
Peptide name
Lethal(3)malignant brain tumor-like protein 2

Ligandability

Cysteine 531 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 583 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lethal(3)malignant brain tumor-like protein 2 between cysteines 197 and 583. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
3cey
Structure name
crystal structure of l3mbtl2
Structure deposition date
2008-02-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
58
Peptide accession
Q969R5
Residue number A
197
Residue number B
583
Peptide name
Lethal(3)malignant brain tumor-like protein 2

Ligandability

Cysteine 197 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 583 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lethal(3)malignant brain tumor-like protein 2 between cysteines 446 and 490. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
3cey
Structure name
crystal structure of l3mbtl2
Structure deposition date
2008-02-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
61
Peptide accession
Q969R5
Residue number A
446
Residue number B
490
Peptide name
Lethal(3)malignant brain tumor-like protein 2

Ligandability

Cysteine 446 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 490 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lethal(3)malignant brain tumor-like protein 2 between cysteines 554 and 594. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
3cey
Structure name
crystal structure of l3mbtl2
Structure deposition date
2008-02-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
80
Peptide accession
Q969R5
Residue number A
554
Residue number B
594
Peptide name
Lethal(3)malignant brain tumor-like protein 2

Ligandability

Cysteine 554 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 594 of Lethal(3)malignant brain tumor-like protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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