Mitochondrial ubiquitin ligase activator of NFKB 1
Intramolecular
Cysteine 302 and cysteine 326
Cysteine 302 and cysteine 323
Cysteine 305 and cysteine 326
Cysteine 336 and cysteine 339
Cysteine 323 and cysteine 326
Cysteine 317 and cysteine 339
Cysteine 302 and cysteine 305
Cysteine 305 and cysteine 323
Cysteine 317 and cysteine 336
Cysteine 302 and cysteine 321
More...Cysteine 321 and cysteine 336
Cysteine 321 and cysteine 339
Cysteine 312 and cysteine 323
Cysteine 312 and cysteine 326
Cysteine 312 and cysteine 321
Cysteine 302 and cysteine 312
Cysteine 317 and cysteine 321
Cysteine 312 and cysteine 317
Cysteine 321 and cysteine 323
Cysteine 321 and cysteine 326
Cysteine 312 and cysteine 336
6m2d A 302 A 326
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 302 and 326.
Details
Redox score ?
87
PDB code
6m2d
Structure name
mul1-ring domain
Structure deposition date
2020-02-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
3
% buried
60
Peptide accession
Q969V5
Residue number A
302
Residue number B
326
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 302 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 326 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2d E 302 E 323
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 302 and 323.
Details
Redox score ?
85
PDB code
6m2d
Structure name
mul1-ring domain
Structure deposition date
2020-02-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
3
% buried
42
Peptide accession
Q969V5
Residue number A
302
Residue number B
323
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 302 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 323 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2c E 305 E 326
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 305 and 326.
Details
Redox score ?
79
PDB code
6m2c
Structure name
distinct mechanism of mul1-ring domain simultaneously recruiting e2 enzyme and the substrate p53-tad domain
Structure deposition date
2020-02-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
7
% buried
44
Peptide accession
Q969V5
Residue number A
305
Residue number B
326
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 305 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 326 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2d D 336 D 339
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 336 and 339.
Details
Redox score ?
76
PDB code
6m2d
Structure name
mul1-ring domain
Structure deposition date
2020-02-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
nan
Peptide accession
Q969V5
Residue number A
336
Residue number B
339
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 336 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 339 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2c E 323 E 326
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 323 and 326.
Details
Redox score ?
74
PDB code
6m2c
Structure name
distinct mechanism of mul1-ring domain simultaneously recruiting e2 enzyme and the substrate p53-tad domain
Structure deposition date
2020-02-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
9
% buried
40
Peptide accession
Q969V5
Residue number A
323
Residue number B
326
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 323 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 326 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2d C 317 C 339
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 317 and 339.
Details
Redox score ?
74
PDB code
6m2d
Structure name
mul1-ring domain
Structure deposition date
2020-02-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
45
Peptide accession
Q969V5
Residue number A
317
Residue number B
339
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 317 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 339 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2d B 302 B 305
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 302 and 305.
Details
Redox score ?
73
PDB code
6m2d
Structure name
mul1-ring domain
Structure deposition date
2020-02-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
8
% buried
nan
Peptide accession
Q969V5
Residue number A
302
Residue number B
305
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 302 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 305 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2c G 305 G 323
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 305 and 323.
Details
Redox score ?
72
PDB code
6m2c
Structure name
distinct mechanism of mul1-ring domain simultaneously recruiting e2 enzyme and the substrate p53-tad domain
Structure deposition date
2020-02-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
7
% buried
36
Peptide accession
Q969V5
Residue number A
305
Residue number B
323
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 305 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 323 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2c H 317 H 336
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 317 and 336.
Details
Redox score ?
70
PDB code
6m2c
Structure name
distinct mechanism of mul1-ring domain simultaneously recruiting e2 enzyme and the substrate p53-tad domain
Structure deposition date
2020-02-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
10
% buried
nan
Peptide accession
Q969V5
Residue number A
317
Residue number B
336
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 317 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 336 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2c H 302 H 321
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 302 and 321.
Details
Redox score ?
63
PDB code
6m2c
Structure name
distinct mechanism of mul1-ring domain simultaneously recruiting e2 enzyme and the substrate p53-tad domain
Structure deposition date
2020-02-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
3
% buried
74
Peptide accession
Q969V5
Residue number A
302
Residue number B
321
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 302 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 321 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2d C 321 C 336
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 321 and 336. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
6m2d
Structure name
mul1-ring domain
Structure deposition date
2020-02-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
15
% buried
nan
Peptide accession
Q969V5
Residue number A
321
Residue number B
336
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 321 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 336 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2d F 321 F 339
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 321 and 339. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
6m2d
Structure name
mul1-ring domain
Structure deposition date
2020-02-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
43
Peptide accession
Q969V5
Residue number A
321
Residue number B
339
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 321 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 339 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2c G 312 G 323
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 312 and 323. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
6m2c
Structure name
distinct mechanism of mul1-ring domain simultaneously recruiting e2 enzyme and the substrate p53-tad domain
Structure deposition date
2020-02-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
38
Peptide accession
Q969V5
Residue number A
312
Residue number B
323
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 312 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 323 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2d A 312 A 326
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 312 and 326. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
6m2d
Structure name
mul1-ring domain
Structure deposition date
2020-02-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
9
% buried
40
Peptide accession
Q969V5
Residue number A
312
Residue number B
326
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 312 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 326 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2d E 312 E 321
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 312 and 321. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
6m2d
Structure name
mul1-ring domain
Structure deposition date
2020-02-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
9
% buried
50
Peptide accession
Q969V5
Residue number A
312
Residue number B
321
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 312 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 321 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2d B 302 B 312
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 302 and 312. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6m2d
Structure name
mul1-ring domain
Structure deposition date
2020-02-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
nan
Peptide accession
Q969V5
Residue number A
302
Residue number B
312
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 302 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 312 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2d C 317 C 321
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 317 and 321. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6m2d
Structure name
mul1-ring domain
Structure deposition date
2020-02-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
15
% buried
62
Peptide accession
Q969V5
Residue number A
317
Residue number B
321
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 317 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 321 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2c G 312 G 317
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 312 and 317. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
6m2c
Structure name
distinct mechanism of mul1-ring domain simultaneously recruiting e2 enzyme and the substrate p53-tad domain
Structure deposition date
2020-02-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
50
Peptide accession
Q969V5
Residue number A
312
Residue number B
317
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 312 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 317 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2d F 321 F 323
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 321 and 323. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
6m2d
Structure name
mul1-ring domain
Structure deposition date
2020-02-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
9
% buried
33
Peptide accession
Q969V5
Residue number A
321
Residue number B
323
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 321 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 323 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2d D 321 D 326
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 321 and 326. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
6m2d
Structure name
mul1-ring domain
Structure deposition date
2020-02-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
12
% buried
31
Peptide accession
Q969V5
Residue number A
321
Residue number B
326
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 321 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 326 of Mitochondrial ubiquitin ligase activator of NFKB 1
6m2d F 312 F 336
A redox-regulated disulphide may form within Mitochondrial ubiquitin ligase activator of NFKB 1 between cysteines 312 and 336. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
6m2d
Structure name
mul1-ring domain
Structure deposition date
2020-02-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
nan
Peptide accession
Q969V5
Residue number A
312
Residue number B
336
Peptide name
Mitochondrial ubiquitin ligase activator of NFKB 1
Ligandability
Cysteine 312 of Mitochondrial ubiquitin ligase activator of NFKB 1
Cysteine 336 of Mitochondrial ubiquitin ligase activator of NFKB 1
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