Insulin gene enhancer protein ISL-2
Intramolecular
Cysteine 55 and cysteine 30
Cysteine 117 and cysteine 120
Cysteine 55 and cysteine 58
Cysteine 55 and cysteine 52
Cysteine 89 and cysteine 92
Cysteine 89 and cysteine 114
Cysteine 117 and cysteine 77
Cysteine 55 and cysteine 77
Cysteine 30 and cysteine 52
Cysteine 120 and cysteine 77
More...Cysteine 58 and cysteine 77
Cysteine 92 and cysteine 114
Cysteine 55 and cysteine 68
6cme B 30 B 33
A redox-regulated disulphide may form within Insulin gene enhancer protein ISL-2 between cysteines 55 and 30 (30 and 33 respectively in this structure).
Details
Redox score ?
85
PDB code
6cme
Structure name
structure of wild-type isl2-lid in complex with lhx4-lim1+2
Structure deposition date
2018-03-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
6
% buried
13
Peptide accession
Q9CXV0
Residue number A
55
Residue number B
30
Peptide name
Insulin gene enhancer protein ISL-2
Ligandability
Cysteine 55 of Insulin gene enhancer protein ISL-2
Cysteine 30 of Insulin gene enhancer protein ISL-2
6cme A 117 A 120
A redox-regulated disulphide may form within Insulin gene enhancer protein ISL-2 between cysteines 117 and 120.
Details
Redox score ?
84
PDB code
6cme
Structure name
structure of wild-type isl2-lid in complex with lhx4-lim1+2
Structure deposition date
2018-03-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
7
% buried
10
Peptide accession
Q9CXV0
Residue number A
117
Residue number B
120
Peptide name
Insulin gene enhancer protein ISL-2
Ligandability
Cysteine 117 of Insulin gene enhancer protein ISL-2
Cysteine 120 of Insulin gene enhancer protein ISL-2
6cme A 57 A 60
A redox-regulated disulphide may form within Insulin gene enhancer protein ISL-2 between cysteines 55 and 58 (57 and 60 respectively in this structure).
Details
Redox score ?
84
PDB code
6cme
Structure name
structure of wild-type isl2-lid in complex with lhx4-lim1+2
Structure deposition date
2018-03-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
7
% buried
4
Peptide accession
Q9CXV0
Residue number A
55
Residue number B
58
Peptide name
Insulin gene enhancer protein ISL-2
Ligandability
Cysteine 55 of Insulin gene enhancer protein ISL-2
Cysteine 58 of Insulin gene enhancer protein ISL-2
6cme A 30 A 54
A redox-regulated disulphide may form within Insulin gene enhancer protein ISL-2 between cysteines 55 and 52 (30 and 54 respectively in this structure).
Details
Redox score ?
83
PDB code
6cme
Structure name
structure of wild-type isl2-lid in complex with lhx4-lim1+2
Structure deposition date
2018-03-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
6
% buried
18
Peptide accession
Q9CXV0
Residue number A
55
Residue number B
52
Peptide name
Insulin gene enhancer protein ISL-2
Ligandability
Cysteine 55 of Insulin gene enhancer protein ISL-2
Cysteine 52 of Insulin gene enhancer protein ISL-2
3mmk A 89 A 92
A redox-regulated disulphide may form within Insulin gene enhancer protein ISL-2 between cysteines 89 and 92.
Details
Redox score ?
83
PDB code
3mmk
Structure name
the structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification
Structure deposition date
2010-04-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
6
% buried
13
Peptide accession
Q9CXV0
Residue number A
89
Residue number B
92
Peptide name
Insulin gene enhancer protein ISL-2
Ligandability
Cysteine 89 of Insulin gene enhancer protein ISL-2
Cysteine 92 of Insulin gene enhancer protein ISL-2
3mmk B 89 B 114
A redox-regulated disulphide may form within Insulin gene enhancer protein ISL-2 between cysteines 89 and 114.
Details
Redox score ?
82
PDB code
3mmk
Structure name
the structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification
Structure deposition date
2010-04-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
6
% buried
24
Peptide accession
Q9CXV0
Residue number A
89
Residue number B
114
Peptide name
Insulin gene enhancer protein ISL-2
Ligandability
Cysteine 89 of Insulin gene enhancer protein ISL-2
Cysteine 114 of Insulin gene enhancer protein ISL-2
3mmk A 117 A 140
A redox-regulated disulphide may form within Insulin gene enhancer protein ISL-2 between cysteines 117 and 77 (117 and 140 respectively in this structure).
Details
Redox score ?
80
PDB code
3mmk
Structure name
the structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification
Structure deposition date
2010-04-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
7
% buried
14
Peptide accession
Q9CXV0
Residue number A
117
Residue number B
77
Peptide name
Insulin gene enhancer protein ISL-2
Ligandability
Cysteine 117 of Insulin gene enhancer protein ISL-2
Cysteine 77 of Insulin gene enhancer protein ISL-2
3mmk A 57 A 77
A redox-regulated disulphide may form within Insulin gene enhancer protein ISL-2 between cysteines 55 and 77 (57 and 77 respectively in this structure).
Details
Redox score ?
79
PDB code
3mmk
Structure name
the structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification
Structure deposition date
2010-04-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
7
% buried
0
Peptide accession
Q9CXV0
Residue number A
55
Residue number B
77
Peptide name
Insulin gene enhancer protein ISL-2
Ligandability
Cysteine 55 of Insulin gene enhancer protein ISL-2
Cysteine 77 of Insulin gene enhancer protein ISL-2
6cme A 33 A 54
A redox-regulated disulphide may form within Insulin gene enhancer protein ISL-2 between cysteines 30 and 52 (33 and 54 respectively in this structure).
Details
Redox score ?
76
PDB code
6cme
Structure name
structure of wild-type isl2-lid in complex with lhx4-lim1+2
Structure deposition date
2018-03-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
5
Peptide accession
Q9CXV0
Residue number A
30
Residue number B
52
Peptide name
Insulin gene enhancer protein ISL-2
Ligandability
Cysteine 30 of Insulin gene enhancer protein ISL-2
Cysteine 52 of Insulin gene enhancer protein ISL-2
3mmk B 120 B 140
A redox-regulated disulphide may form within Insulin gene enhancer protein ISL-2 between cysteines 120 and 77 (120 and 140 respectively in this structure).
Details
Redox score ?
75
PDB code
3mmk
Structure name
the structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification
Structure deposition date
2010-04-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
2
Peptide accession
Q9CXV0
Residue number A
120
Residue number B
77
Peptide name
Insulin gene enhancer protein ISL-2
Ligandability
Cysteine 120 of Insulin gene enhancer protein ISL-2
Cysteine 77 of Insulin gene enhancer protein ISL-2
6cme B 60 B 77
A redox-regulated disulphide may form within Insulin gene enhancer protein ISL-2 between cysteines 58 and 77 (60 and 77 respectively in this structure).
Details
Redox score ?
75
PDB code
6cme
Structure name
structure of wild-type isl2-lid in complex with lhx4-lim1+2
Structure deposition date
2018-03-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
4
Peptide accession
Q9CXV0
Residue number A
58
Residue number B
77
Peptide name
Insulin gene enhancer protein ISL-2
Ligandability
Cysteine 58 of Insulin gene enhancer protein ISL-2
Cysteine 77 of Insulin gene enhancer protein ISL-2
3mmk A 92 A 114
A redox-regulated disulphide may form within Insulin gene enhancer protein ISL-2 between cysteines 92 and 114.
Details
Redox score ?
74
PDB code
3mmk
Structure name
the structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification
Structure deposition date
2010-04-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
5
Peptide accession
Q9CXV0
Residue number A
92
Residue number B
114
Peptide name
Insulin gene enhancer protein ISL-2
Ligandability
Cysteine 92 of Insulin gene enhancer protein ISL-2
Cysteine 114 of Insulin gene enhancer protein ISL-2
6cme B 57 B 68
A redox-regulated disulphide may form within Insulin gene enhancer protein ISL-2 between cysteines 55 and 68 (57 and 68 respectively in this structure).
Details
Redox score ?
nan
PDB code
6cme
Structure name
structure of wild-type isl2-lid in complex with lhx4-lim1+2
Structure deposition date
2018-03-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
7
% buried
30
Peptide accession
Q9CXV0
Residue number A
55
Residue number B
68
Peptide name
Insulin gene enhancer protein ISL-2
Ligandability
Cysteine 55 of Insulin gene enhancer protein ISL-2
Cysteine 68 of Insulin gene enhancer protein ISL-2
Uncertain whether structure cysteine 68 has been assigned to correct residue.
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