ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Adiponectin receptor protein 1

Intramolecular
Cysteine 124 and cysteine 195
Cysteine 230 and cysteine 369
A redox-regulated disulphide may form within Adiponectin receptor protein 1 between cysteines 124 and 195.

Details

Redox score ?
72
PDB code
6krz
Structure name
crystal structure of the human adiponectin receptor 1 d208a mutant
Structure deposition date
2018-08-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
7
% buried
100
Peptide accession
Q96A54
Residue number A
124
Residue number B
195
Peptide name
Adiponectin receptor protein 1

Ligandability

Cysteine 124 of Adiponectin receptor protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 of Adiponectin receptor protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Adiponectin receptor protein 1 between cysteines 230 and 369. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
6ks0
Structure name
crystal structure of the human adiponectin receptor 1
Structure deposition date
2018-08-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
31
Minimum pKa ?
9
% buried
8
Peptide accession
Q96A54
Residue number A
230
Residue number B
369
Peptide name
Adiponectin receptor protein 1

Ligandability

Cysteine 230 of Adiponectin receptor protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 369 of Adiponectin receptor protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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