ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein N-terminal asparagine amidohydrolase

Intramolecular
Cysteine 89 and cysteine 93
Cysteine 75 and cysteine 93
A redox-regulated disulphide may form within Protein N-terminal asparagine amidohydrolase between cysteines 89 and 93. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
6a0h
Structure name
crystal structure of human protein n-terminal asparagine amidohydrolase (ntan1) c75s mutant with asn-leu-ala-ala-arg peptide
Structure deposition date
2018-06-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
97
Minimum pKa ?
12
% buried
100
Peptide accession
Q96AB6
Residue number A
89
Residue number B
93
Peptide name
Protein N-terminal asparagine amidohydrolase

Ligandability

Cysteine 89 of Protein N-terminal asparagine amidohydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Protein N-terminal asparagine amidohydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein N-terminal asparagine amidohydrolase between cysteines 75 and 93. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
6a0e
Structure name
crystal structure of human protein n-terminal asparagine amidohydrolase (ntan1)
Structure deposition date
2018-06-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
91
Minimum pKa ?
12
% buried
100
Peptide accession
Q96AB6
Residue number A
75
Residue number B
93
Peptide name
Protein N-terminal asparagine amidohydrolase

Ligandability

Cysteine 75 of Protein N-terminal asparagine amidohydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Protein N-terminal asparagine amidohydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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