ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ribulose-phosphate 3-epimerase

Intramolecular
Cysteine 5 and cysteine 217
Cysteine 186 and cysteine 217
A redox-regulated disulphide may form within Ribulose-phosphate 3-epimerase between cysteines 5 and 217.

Details

Redox score ?
73
PDB code
3ovp
Structure name
crystal structure of hrpe
Structure deposition date
2010-09-16
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
7
% buried
60
Peptide accession
Q96AT9
Residue number A
5
Residue number B
217
Peptide name
Ribulose-phosphate 3-epimerase

Ligandability

Cysteine 5 of Ribulose-phosphate 3-epimerase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 217 of Ribulose-phosphate 3-epimerase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribulose-phosphate 3-epimerase between cysteines 186 and 217. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
3qc3
Structure name
crystal structure of a d-ribulose-5-phosphate-3-epimerase (np_954699) from homo sapiens at 2
Structure deposition date
2011-01-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
nan
Peptide accession
Q96AT9
Residue number A
186
Residue number B
217
Peptide name
Ribulose-phosphate 3-epimerase

Ligandability

Cysteine 186 of Ribulose-phosphate 3-epimerase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 217 of Ribulose-phosphate 3-epimerase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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