ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Crossover junction endonuclease EME1

Intramolecular
Cysteine 278 and cysteine 280
Cysteine 278 and cysteine 437
Cysteine 280 and cysteine 437
Cysteine 248 and cysteine 278
A redox-regulated disulphide may form within Crossover junction endonuclease EME1 between cysteines 278 and 280.

Details

Redox score ?
72
PDB code
4p0s
Structure name
human mus81-eme1-3'flap dna complex
Structure deposition date
2014-02-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
8
% buried
86
Peptide accession
Q96AY2
Residue number A
278
Residue number B
280
Peptide name
Crossover junction endonuclease EME1

Ligandability

Cysteine 278 of Crossover junction endonuclease EME1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 280 of Crossover junction endonuclease EME1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Crossover junction endonuclease EME1 between cysteines 278 and 437. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
4p0s
Structure name
human mus81-eme1-3'flap dna complex
Structure deposition date
2014-02-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
8
% buried
66
Peptide accession
Q96AY2
Residue number A
278
Residue number B
437
Peptide name
Crossover junction endonuclease EME1

Ligandability

Cysteine 278 of Crossover junction endonuclease EME1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 437 of Crossover junction endonuclease EME1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Crossover junction endonuclease EME1 between cysteines 280 and 437. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
4p0q
Structure name
crystal structure of human mus81-eme1 in complex with 5'-flap dna
Structure deposition date
2014-02-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
56
Peptide accession
Q96AY2
Residue number A
280
Residue number B
437
Peptide name
Crossover junction endonuclease EME1

Ligandability

Cysteine 280 of Crossover junction endonuclease EME1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 437 of Crossover junction endonuclease EME1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Crossover junction endonuclease EME1 between cysteines 248 and 278. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
4p0q
Structure name
crystal structure of human mus81-eme1 in complex with 5'-flap dna
Structure deposition date
2014-02-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
12
% buried
67
Peptide accession
Q96AY2
Residue number A
248
Residue number B
278
Peptide name
Crossover junction endonuclease EME1

Ligandability

Cysteine 248 of Crossover junction endonuclease EME1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 278 of Crossover junction endonuclease EME1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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