ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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EEF1A lysine methyltransferase 3

Intramolecular
Cysteine 36 and cysteine 64
Cysteine 34 and cysteine 36
A redox-regulated disulphide may form within EEF1A lysine methyltransferase 3 between cysteines 36 and 64. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
4qpn
Structure name
crystal structure of human methyltransferase-like protein 21b
Structure deposition date
2014-06-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96AZ1
Residue number A
36
Residue number B
64
Peptide name
EEF1A lysine methyltransferase 3

Ligandability

Cysteine 36 of EEF1A lysine methyltransferase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 64 of EEF1A lysine methyltransferase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within EEF1A lysine methyltransferase 3 between cysteines 34 and 36. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
4qpn
Structure name
crystal structure of human methyltransferase-like protein 21b
Structure deposition date
2014-06-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96AZ1
Residue number A
34
Residue number B
36
Peptide name
EEF1A lysine methyltransferase 3

Ligandability

Cysteine 34 of EEF1A lysine methyltransferase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 36 of EEF1A lysine methyltransferase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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