ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ubiquitin-conjugating enzyme E2 W

Intramolecular
Cysteine 91 and cysteine 151
Cysteine 91 and cysteine 135
Cysteine 91 and cysteine 119
A redox-regulated disulphide may form within Ubiquitin-conjugating enzyme E2 W between cysteines 91 and 151.

Details

Redox score ?
63
PDB code
2mt6
Structure name
solution structure of the human ubiquitin conjugating enzyme ube2w
Structure deposition date
2014-08-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
16
Peptide accession
Q96B02
Residue number A
91
Residue number B
151
Peptide name
Ubiquitin-conjugating enzyme E2 W

Ligandability

Cysteine 91 of Ubiquitin-conjugating enzyme E2 W

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 151 of Ubiquitin-conjugating enzyme E2 W

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubiquitin-conjugating enzyme E2 W between cysteines 91 and 135. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
2mt6
Structure name
solution structure of the human ubiquitin conjugating enzyme ube2w
Structure deposition date
2014-08-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
16
Peptide accession
Q96B02
Residue number A
91
Residue number B
135
Peptide name
Ubiquitin-conjugating enzyme E2 W

Ligandability

Cysteine 91 of Ubiquitin-conjugating enzyme E2 W

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 135 of Ubiquitin-conjugating enzyme E2 W

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubiquitin-conjugating enzyme E2 W between cysteines 91 and 119. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2mt6
Structure name
solution structure of the human ubiquitin conjugating enzyme ube2w
Structure deposition date
2014-08-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
18
Peptide accession
Q96B02
Residue number A
91
Residue number B
119
Peptide name
Ubiquitin-conjugating enzyme E2 W

Ligandability

Cysteine 91 of Ubiquitin-conjugating enzyme E2 W

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 119 of Ubiquitin-conjugating enzyme E2 W

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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