ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Exosome complex component RRP43

Intramolecular
Cysteine 89 and cysteine 141
Cysteine 233 and cysteine 234
Cysteine 60 and cysteine 137
Cysteine 141 and cysteine 152
Cysteine 60 and cysteine 152
A redox-regulated disulphide may form within Exosome complex component RRP43 between cysteines 89 and 141.

Details

Redox score ?
63
PDB code
2nn6
Structure name
structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40
Structure deposition date
2006-10-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
85
Minimum pKa ?
10
% buried
100
Peptide accession
Q96B26
Residue number A
89
Residue number B
141
Peptide name
Exosome complex component RRP43

Ligandability

Cysteine 89 of Exosome complex component RRP43

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 141 of Exosome complex component RRP43

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exosome complex component RRP43 between cysteines 233 and 234.

Details

Redox score ?
63
PDB code
2nn6
Structure name
structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40
Structure deposition date
2006-10-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
86
Minimum pKa ?
10
% buried
100
Peptide accession
Q96B26
Residue number A
233
Residue number B
234
Peptide name
Exosome complex component RRP43

Ligandability

Cysteine 233 of Exosome complex component RRP43

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 234 of Exosome complex component RRP43

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exosome complex component RRP43 between cysteines 60 and 137. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
2nn6
Structure name
structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40
Structure deposition date
2006-10-23
Thiol separation (Å)
5
Half-sphere exposure sum ?
102
Minimum pKa ?
13
% buried
100
Peptide accession
Q96B26
Residue number A
60
Residue number B
137
Peptide name
Exosome complex component RRP43

Ligandability

Cysteine 60 of Exosome complex component RRP43

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 137 of Exosome complex component RRP43

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exosome complex component RRP43 between cysteines 141 and 152. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2nn6
Structure name
structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40
Structure deposition date
2006-10-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
92
Minimum pKa ?
12
% buried
100
Peptide accession
Q96B26
Residue number A
141
Residue number B
152
Peptide name
Exosome complex component RRP43

Ligandability

Cysteine 141 of Exosome complex component RRP43

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 152 of Exosome complex component RRP43

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exosome complex component RRP43 between cysteines 60 and 152. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
2nn6
Structure name
structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40
Structure deposition date
2006-10-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
103
Minimum pKa ?
12
% buried
100
Peptide accession
Q96B26
Residue number A
60
Residue number B
152
Peptide name
Exosome complex component RRP43

Ligandability

Cysteine 60 of Exosome complex component RRP43

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 152 of Exosome complex component RRP43

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: