ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Spindle and kinetochore-associated protein 1

Intermolecular
Cysteine 74 and cysteine 79 of Spindle and kinetochore-associated protein 2
Cysteine 10 and cysteine 10
A redox-regulated disulphide may form between cysteine 74 of Spindle and kinetochore-associated protein 1 and cysteine 79 of Spindle and kinetochore-associated protein 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
4aj5
Structure name
crystal structure of the ska core complex
Structure deposition date
2012-02-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
16
Peptide A name
Spindle and kinetochore-associated protein 1
Peptide B name
Spindle and kinetochore-associated protein 2
Peptide A accession
Q96BD8
Peptide B accession
Q8WVK7
Peptide A residue number
74
Peptide B residue number
79

Ligandability

Cysteine 74 of Spindle and kinetochore-associated protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 79 of Spindle and kinetochore-associated protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Spindle and kinetochore-associated protein 1 at cysteines 10 and 10. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
4aj5
Structure name
crystal structure of the ska core complex
Structure deposition date
2012-02-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
100
Peptide A name
Spindle and kinetochore-associated protein 1
Peptide B name
Spindle and kinetochore-associated protein 1
Peptide A accession
Q96BD8
Peptide B accession
Q96BD8
Peptide A residue number
10
Peptide B residue number
10

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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