a tool for identifying drug-targetable redox-active disulphides

Axin interactor, dorsalization-associated protein

Intramolecular

Cysteine 183 and cysteine 256

A redox-regulated disulphide may form within Axin interactor, dorsalization-associated protein between cysteines 183 and 256 (49 and 122 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

43

PDB code

Structure name

crystal structure of the c-terminal domain of aida

Structure deposition date

2007-08-16

Thiol separation (Å)

8

Half-sphere exposure sum ?

67

Minimum pK_a ?

11

% buried

75

Peptide accession

Residue number A

183

Residue number B

256

Peptide name

Axin interactor, dorsalization-associated protein

Ligandability

Cysteine 183 of Axin interactor, dorsalization-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 256 of Axin interactor, dorsalization-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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