ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transcriptional adapter 1

Intermolecular
Cysteine 2657 of Transformation/transcription domain-associated protein and cysteine 263
Cysteine 2639 of Transformation/transcription domain-associated protein and cysteine 263
A redox-regulated disulphide may form between cysteine 2657 of Transformation/transcription domain-associated protein and cysteine 263 of Transcriptional adapter 1.

Details

Redox score ?
72
PDB code
8h7g
Structure name
cryo-em structure of the human saga complex
Structure deposition date
2022-10-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
7
% buried
70
Peptide A name
Transformation/transcription domain-associated protein
Peptide B name
Transcriptional adapter 1
Peptide A accession
Q9Y4A5
Peptide B accession
Q96BN2
Peptide A residue number
2657
Peptide B residue number
263

Ligandability

Cysteine 2657 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 263 of Transcriptional adapter 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 2639 of Transformation/transcription domain-associated protein and cysteine 263 of Transcriptional adapter 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7ktr
Structure name
cryo-em structure of the human saga coactivator complex (trrap, core)
Structure deposition date
2020-11-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
98
Peptide A name
Transformation/transcription domain-associated protein
Peptide B name
Transcriptional adapter 1
Peptide A accession
F2Z2U4
Peptide B accession
Q96BN2
Peptide A residue number
2639
Peptide B residue number
263

Ligandability

Cysteine 2639 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 263 of Transcriptional adapter 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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