ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cytochrome c oxidase assembly factor 7

Intramolecular
Cysteine 28 and cysteine 37 L
Cysteine 62 and cysteine 71 L
Cysteine 179 and cysteine 187
Cysteine 142 and cysteine 150
Cysteine 100 and cysteine 111
Cysteine 62 and cysteine 95 L
Cysteine 71 and cysteine 95 L
Cysteine 24 and cysteine 28
Cysteine 24 and cysteine 37 L
Cysteine 172 and cysteine 179
A redox-regulated disulphide may form within Cytochrome c oxidase assembly factor 7 between cysteines 28 and 37.

Details

Redox score ?
84
PDB code
7mqz
Structure name
cytochrome c oxidase assembly factor 7
Structure deposition date
2021-05-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96BR5
Residue number A
28
Residue number B
37
Peptide name
Cytochrome c oxidase assembly factor 7

Ligandability

Cysteine 28 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 37 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome c oxidase assembly factor 7 between cysteines 62 and 71.

Details

Redox score ?
81
PDB code
7mqz
Structure name
cytochrome c oxidase assembly factor 7
Structure deposition date
2021-05-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96BR5
Residue number A
62
Residue number B
71
Peptide name
Cytochrome c oxidase assembly factor 7

Ligandability

Cysteine 62 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 71 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome c oxidase assembly factor 7 between cysteines 179 and 187.

Details

Redox score ?
81
PDB code
7mqz
Structure name
cytochrome c oxidase assembly factor 7
Structure deposition date
2021-05-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96BR5
Residue number A
179
Residue number B
187
Peptide name
Cytochrome c oxidase assembly factor 7

Ligandability

Cysteine 179 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome c oxidase assembly factor 7 between cysteines 142 and 150.

Details

Redox score ?
80
PDB code
7mqz
Structure name
cytochrome c oxidase assembly factor 7
Structure deposition date
2021-05-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96BR5
Residue number A
142
Residue number B
150
Peptide name
Cytochrome c oxidase assembly factor 7

Ligandability

Cysteine 142 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 150 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome c oxidase assembly factor 7 between cysteines 100 and 111.

Details

Redox score ?
79
PDB code
7mqz
Structure name
cytochrome c oxidase assembly factor 7
Structure deposition date
2021-05-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96BR5
Residue number A
100
Residue number B
111
Peptide name
Cytochrome c oxidase assembly factor 7

Ligandability

Cysteine 100 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 111 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome c oxidase assembly factor 7 between cysteines 62 and 95.

Details

Redox score ?
64
PDB code
7mqz
Structure name
cytochrome c oxidase assembly factor 7
Structure deposition date
2021-05-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
nan
Peptide accession
Q96BR5
Residue number A
62
Residue number B
95
Peptide name
Cytochrome c oxidase assembly factor 7

Ligandability

Cysteine 62 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 95 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome c oxidase assembly factor 7 between cysteines 71 and 95. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7mqz
Structure name
cytochrome c oxidase assembly factor 7
Structure deposition date
2021-05-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
84
Minimum pKa ?
11
% buried
nan
Peptide accession
Q96BR5
Residue number A
71
Residue number B
95
Peptide name
Cytochrome c oxidase assembly factor 7

Ligandability

Cysteine 71 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 95 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome c oxidase assembly factor 7 between cysteines 24 and 28. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7mqz
Structure name
cytochrome c oxidase assembly factor 7
Structure deposition date
2021-05-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
nan
Peptide accession
Q96BR5
Residue number A
24
Residue number B
28
Peptide name
Cytochrome c oxidase assembly factor 7

Ligandability

Cysteine 24 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 28 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome c oxidase assembly factor 7 between cysteines 24 and 37. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7mqz
Structure name
cytochrome c oxidase assembly factor 7
Structure deposition date
2021-05-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
nan
Peptide accession
Q96BR5
Residue number A
24
Residue number B
37
Peptide name
Cytochrome c oxidase assembly factor 7

Ligandability

Cysteine 24 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 37 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome c oxidase assembly factor 7 between cysteines 172 and 179. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7mqz
Structure name
cytochrome c oxidase assembly factor 7
Structure deposition date
2021-05-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
10
% buried
nan
Peptide accession
Q96BR5
Residue number A
172
Residue number B
179
Peptide name
Cytochrome c oxidase assembly factor 7

Ligandability

Cysteine 172 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Cytochrome c oxidase assembly factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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