ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Centromere protein T

Intermolecular
Cysteine 152 of Centromere protein I and cysteine 550
Cysteine 486 and cysteine 47 of Centromere protein W
A redox-regulated disulphide may form between cysteine 152 of Centromere protein I and cysteine 550 of Centromere protein T. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7xho
Structure name
structure of human inner kinetochore ccan complex
Structure deposition date
2022-04-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
77
Peptide A name
Centromere protein I
Peptide B name
Centromere protein T
Peptide A accession
Q92674
Peptide B accession
Q96BT3
Peptide A residue number
152
Peptide B residue number
550

Ligandability

Cysteine 152 of Centromere protein I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 550 of Centromere protein T

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 486 of Centromere protein T and cysteine 47 of Centromere protein W. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
7qoo
Structure name
structure of the human inner kinetochore ccan complex
Structure deposition date
2021-12-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
11
% buried
88
Peptide A name
Centromere protein T
Peptide B name
Centromere protein W
Peptide A accession
Q96BT3
Peptide B accession
Q5EE01
Peptide A residue number
486
Peptide B residue number
47

Ligandability

Cysteine 486 of Centromere protein T

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 47 of Centromere protein W

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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