ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Alkylated DNA repair protein alkB homolog 8

Intramolecular
Cysteine 341 and cysteine 343
Cysteine 341 and cysteine 349
Cysteine 343 and cysteine 349
A redox-regulated disulphide may form within Alkylated DNA repair protein alkB homolog 8 between cysteines 341 and 343.

Details

Redox score ?
88
PDB code
3tht
Structure name
crystal structure and rna binding properties of the rrm/alkb domains in human abh8, an enzyme catalyzing trna hypermodification, northeast structural genomics consortium target hr5601b
Structure deposition date
2011-08-19
Thiol separation (Å)
3
Half-sphere exposure sum ?
52
Minimum pKa ?
7
% buried
24
Peptide accession
Q96BT7
Residue number A
341
Residue number B
343
Peptide name
Alkylated DNA repair protein alkB homolog 8

Ligandability

Cysteine 341 of Alkylated DNA repair protein alkB homolog 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 343 of Alkylated DNA repair protein alkB homolog 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Alkylated DNA repair protein alkB homolog 8 between cysteines 341 and 349.

Details

Redox score ?
86
PDB code
3tht
Structure name
crystal structure and rna binding properties of the rrm/alkb domains in human abh8, an enzyme catalyzing trna hypermodification, northeast structural genomics consortium target hr5601b
Structure deposition date
2011-08-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
7
% buried
25
Peptide accession
Q96BT7
Residue number A
341
Residue number B
349
Peptide name
Alkylated DNA repair protein alkB homolog 8

Ligandability

Cysteine 341 of Alkylated DNA repair protein alkB homolog 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 349 of Alkylated DNA repair protein alkB homolog 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Alkylated DNA repair protein alkB homolog 8 between cysteines 343 and 349.

Details

Redox score ?
82
PDB code
3tht
Structure name
crystal structure and rna binding properties of the rrm/alkb domains in human abh8, an enzyme catalyzing trna hypermodification, northeast structural genomics consortium target hr5601b
Structure deposition date
2011-08-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
7
% buried
20
Peptide accession
Q96BT7
Residue number A
343
Residue number B
349
Peptide name
Alkylated DNA repair protein alkB homolog 8

Ligandability

Cysteine 343 of Alkylated DNA repair protein alkB homolog 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 349 of Alkylated DNA repair protein alkB homolog 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: