ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dedicator of cytokinesis protein 10

Intramolecular
Cysteine 2047 and cysteine 2108
Cysteine 1722 and cysteine 1816
A redox-regulated disulphide may form within Dedicator of cytokinesis protein 10 between cysteines 2047 and 2108. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6tkz
Structure name
crystal structure of the dhr2 domain of dock10 in complex with cdc42
Structure deposition date
2019-11-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
72
Peptide accession
Q96BY6
Residue number A
2047
Residue number B
2108
Peptide name
Dedicator of cytokinesis protein 10

Ligandability

Cysteine 2047 of Dedicator of cytokinesis protein 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2108 of Dedicator of cytokinesis protein 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dedicator of cytokinesis protein 10 between cysteines 1722 and 1816. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
6tm1
Structure name
crystal structure of the dhr2 domain of dock10 in complex with rac3
Structure deposition date
2019-12-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
81
Peptide accession
Q96BY6
Residue number A
1722
Residue number B
1816
Peptide name
Dedicator of cytokinesis protein 10

Ligandability

Cysteine 1722 of Dedicator of cytokinesis protein 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1816 of Dedicator of cytokinesis protein 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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