ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Synaptotagmin-like protein 4

Intramolecular
Cysteine 63 and cysteine 66
Cysteine 63 and cysteine 91
Cysteine 80 and cysteine 83
Cysteine 80 and cysteine 102
Cysteine 63 and cysteine 88
Cysteine 80 and cysteine 105
Cysteine 102 and cysteine 105
Cysteine 83 and cysteine 102
Cysteine 88 and cysteine 91
Cysteine 66 and cysteine 88
More...
Cysteine 83 and cysteine 105
Cysteine 66 and cysteine 91
Cysteine 63 and cysteine 102
Cysteine 63 and cysteine 80
Cysteine 91 and cysteine 102
Cysteine 63 and cysteine 83
Cysteine 380 and cysteine 477
A redox-regulated disulphide may form within Synaptotagmin-like protein 4 between cysteines 63 and 66 (5 and 8 respectively in this structure).

Details

Redox score ?
90
PDB code
5x6t
Structure name
n-terminal zinc finger of synaptotagmin-like protein 4
Structure deposition date
2017-02-23
Thiol separation (Å)
3
Half-sphere exposure sum ?
49
Minimum pKa ?
5
% buried
6
Peptide accession
Q96C24
Residue number A
63
Residue number B
66
Peptide name
Synaptotagmin-like protein 4

Ligandability

Cysteine 63 of Synaptotagmin-like protein 4

Cysteine 66 of Synaptotagmin-like protein 4

A redox-regulated disulphide may form within Synaptotagmin-like protein 4 between cysteines 63 and 91 (5 and 33 respectively in this structure).

Details

Redox score ?
89
PDB code
5x6t
Structure name
n-terminal zinc finger of synaptotagmin-like protein 4
Structure deposition date
2017-02-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
5
% buried
8
Peptide accession
Q96C24
Residue number A
63
Residue number B
91
Peptide name
Synaptotagmin-like protein 4

Ligandability

Cysteine 63 of Synaptotagmin-like protein 4

Cysteine 91 of Synaptotagmin-like protein 4

A redox-regulated disulphide may form within Synaptotagmin-like protein 4 between cysteines 80 and 83 (45 and 48 respectively in this structure).

Details

Redox score ?
88
PDB code
2csz
Structure name
solution structure of the ring domain of the synaptotagmin-like protein 4
Structure deposition date
2005-05-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
6
% buried
6
Peptide accession
Q96C24
Residue number A
80
Residue number B
83
Peptide name
Synaptotagmin-like protein 4

Ligandability

Cysteine 80 of Synaptotagmin-like protein 4

Cysteine 83 of Synaptotagmin-like protein 4

A redox-regulated disulphide may form within Synaptotagmin-like protein 4 between cysteines 80 and 102 (45 and 67 respectively in this structure).

Details

Redox score ?
86
PDB code
2csz
Structure name
solution structure of the ring domain of the synaptotagmin-like protein 4
Structure deposition date
2005-05-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
6
% buried
8
Peptide accession
Q96C24
Residue number A
80
Residue number B
102
Peptide name
Synaptotagmin-like protein 4

Ligandability

Cysteine 80 of Synaptotagmin-like protein 4

Cysteine 102 of Synaptotagmin-like protein 4

A redox-regulated disulphide may form within Synaptotagmin-like protein 4 between cysteines 63 and 88 (5 and 30 respectively in this structure).

Details

Redox score ?
85
PDB code
5x6t
Structure name
n-terminal zinc finger of synaptotagmin-like protein 4
Structure deposition date
2017-02-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
5
% buried
8
Peptide accession
Q96C24
Residue number A
63
Residue number B
88
Peptide name
Synaptotagmin-like protein 4

Ligandability

Cysteine 63 of Synaptotagmin-like protein 4

Cysteine 88 of Synaptotagmin-like protein 4

A redox-regulated disulphide may form within Synaptotagmin-like protein 4 between cysteines 80 and 105 (45 and 70 respectively in this structure).

Details

Redox score ?
85
PDB code
2csz
Structure name
solution structure of the ring domain of the synaptotagmin-like protein 4
Structure deposition date
2005-05-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
6
% buried
4
Peptide accession
Q96C24
Residue number A
80
Residue number B
105
Peptide name
Synaptotagmin-like protein 4

Ligandability

Cysteine 80 of Synaptotagmin-like protein 4

Cysteine 105 of Synaptotagmin-like protein 4

A redox-regulated disulphide may form within Synaptotagmin-like protein 4 between cysteines 102 and 105 (67 and 70 respectively in this structure).

Details

Redox score ?
82
PDB code
2csz
Structure name
solution structure of the ring domain of the synaptotagmin-like protein 4
Structure deposition date
2005-05-23
Thiol separation (Å)
3
Half-sphere exposure sum ?
59
Minimum pKa ?
7
% buried
3
Peptide accession
Q96C24
Residue number A
102
Residue number B
105
Peptide name
Synaptotagmin-like protein 4

Ligandability

Cysteine 102 of Synaptotagmin-like protein 4

Cysteine 105 of Synaptotagmin-like protein 4

A redox-regulated disulphide may form within Synaptotagmin-like protein 4 between cysteines 83 and 102 (48 and 67 respectively in this structure).

Details

Redox score ?
81
PDB code
2csz
Structure name
solution structure of the ring domain of the synaptotagmin-like protein 4
Structure deposition date
2005-05-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
7
% buried
4
Peptide accession
Q96C24
Residue number A
83
Residue number B
102
Peptide name
Synaptotagmin-like protein 4

Ligandability

Cysteine 83 of Synaptotagmin-like protein 4

Cysteine 102 of Synaptotagmin-like protein 4

A redox-regulated disulphide may form within Synaptotagmin-like protein 4 between cysteines 88 and 91 (53 and 56 respectively in this structure).

Details

Redox score ?
80
PDB code
2csz
Structure name
solution structure of the ring domain of the synaptotagmin-like protein 4
Structure deposition date
2005-05-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
8
% buried
4
Peptide accession
Q96C24
Residue number A
88
Residue number B
91
Peptide name
Synaptotagmin-like protein 4

Ligandability

Cysteine 88 of Synaptotagmin-like protein 4

Cysteine 91 of Synaptotagmin-like protein 4

A redox-regulated disulphide may form within Synaptotagmin-like protein 4 between cysteines 66 and 88 (31 and 53 respectively in this structure).

Details

Redox score ?
77
PDB code
2csz
Structure name
solution structure of the ring domain of the synaptotagmin-like protein 4
Structure deposition date
2005-05-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
8
% buried
3
Peptide accession
Q96C24
Residue number A
66
Residue number B
88
Peptide name
Synaptotagmin-like protein 4

Ligandability

Cysteine 66 of Synaptotagmin-like protein 4

Cysteine 88 of Synaptotagmin-like protein 4

A redox-regulated disulphide may form within Synaptotagmin-like protein 4 between cysteines 83 and 105 (48 and 70 respectively in this structure).

Details

Redox score ?
75
PDB code
2csz
Structure name
solution structure of the ring domain of the synaptotagmin-like protein 4
Structure deposition date
2005-05-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
10
% buried
1
Peptide accession
Q96C24
Residue number A
83
Residue number B
105
Peptide name
Synaptotagmin-like protein 4

Ligandability

Cysteine 83 of Synaptotagmin-like protein 4

Cysteine 105 of Synaptotagmin-like protein 4

A redox-regulated disulphide may form within Synaptotagmin-like protein 4 between cysteines 66 and 91 (31 and 56 respectively in this structure).

Details

Redox score ?
73
PDB code
2csz
Structure name
solution structure of the ring domain of the synaptotagmin-like protein 4
Structure deposition date
2005-05-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
11
% buried
2
Peptide accession
Q96C24
Residue number A
66
Residue number B
91
Peptide name
Synaptotagmin-like protein 4

Ligandability

Cysteine 66 of Synaptotagmin-like protein 4

Cysteine 91 of Synaptotagmin-like protein 4

A redox-regulated disulphide may form within Synaptotagmin-like protein 4 between cysteines 63 and 102 (28 and 67 respectively in this structure).

Details

Redox score ?
61
PDB code
2csz
Structure name
solution structure of the ring domain of the synaptotagmin-like protein 4
Structure deposition date
2005-05-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
5
% buried
8
Peptide accession
Q96C24
Residue number A
63
Residue number B
102
Peptide name
Synaptotagmin-like protein 4

Ligandability

Cysteine 63 of Synaptotagmin-like protein 4

Cysteine 102 of Synaptotagmin-like protein 4

A redox-regulated disulphide may form within Synaptotagmin-like protein 4 between cysteines 63 and 80 (28 and 45 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
2csz
Structure name
solution structure of the ring domain of the synaptotagmin-like protein 4
Structure deposition date
2005-05-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
5
% buried
10
Peptide accession
Q96C24
Residue number A
63
Residue number B
80
Peptide name
Synaptotagmin-like protein 4

Ligandability

Cysteine 63 of Synaptotagmin-like protein 4

Cysteine 80 of Synaptotagmin-like protein 4

A redox-regulated disulphide may form within Synaptotagmin-like protein 4 between cysteines 91 and 102 (33 and 44 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
5x6t
Structure name
n-terminal zinc finger of synaptotagmin-like protein 4
Structure deposition date
2017-02-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
8
% buried
8
Peptide accession
Q96C24
Residue number A
91
Residue number B
102
Peptide name
Synaptotagmin-like protein 4

Ligandability

Cysteine 91 of Synaptotagmin-like protein 4

Cysteine 102 of Synaptotagmin-like protein 4

A redox-regulated disulphide may form within Synaptotagmin-like protein 4 between cysteines 63 and 83 (28 and 48 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
2csz
Structure name
solution structure of the ring domain of the synaptotagmin-like protein 4
Structure deposition date
2005-05-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
47
Minimum pKa ?
5
% buried
6
Peptide accession
Q96C24
Residue number A
63
Residue number B
83
Peptide name
Synaptotagmin-like protein 4

Ligandability

Cysteine 63 of Synaptotagmin-like protein 4

Cysteine 83 of Synaptotagmin-like protein 4

A redox-regulated disulphide may form within Synaptotagmin-like protein 4 between cysteines 380 and 477. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
3fdw
Structure name
crystal structure of a c2 domain from human synaptotagmin-like protein 4
Structure deposition date
2008-11-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
8
% buried
53
Peptide accession
Q96C24
Residue number A
380
Residue number B
477
Peptide name
Synaptotagmin-like protein 4

Ligandability

Cysteine 380 of Synaptotagmin-like protein 4

Cysteine 477 of Synaptotagmin-like protein 4

If this tool was useful for finding a disulphide, please cite: