ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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5-methylcytosine rRNA methyltransferase NSUN4

Intramolecular
Cysteine 258 and cysteine 310
Cysteine 196 and cysteine 197
Cysteine 358 and cysteine 378
Cysteine 181 and cysteine 258
A redox-regulated disulphide may form within 5-methylcytosine rRNA methyltransferase NSUN4 between cysteines 258 and 310.

Details

Redox score ?
74
PDB code
4fp9
Structure name
human mterf4-nsun4 protein complex
Structure deposition date
2012-06-21
Thiol separation (Å)
3
Half-sphere exposure sum ?
75
Minimum pKa ?
8
% buried
100
Peptide accession
Q96CB9
Residue number A
258
Residue number B
310
Peptide name
5-methylcytosine rRNA methyltransferase NSUN4

Ligandability

Cysteine 258 of 5-methylcytosine rRNA methyltransferase NSUN4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of 5-methylcytosine rRNA methyltransferase NSUN4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 5-methylcytosine rRNA methyltransferase NSUN4 between cysteines 196 and 197. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
4fzv
Structure name
crystal structure of the human mterf4:nsun4:sam ternary complex
Structure deposition date
2012-07-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
70
Peptide accession
Q96CB9
Residue number A
196
Residue number B
197
Peptide name
5-methylcytosine rRNA methyltransferase NSUN4

Ligandability

Cysteine 196 of 5-methylcytosine rRNA methyltransferase NSUN4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 197 of 5-methylcytosine rRNA methyltransferase NSUN4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 5-methylcytosine rRNA methyltransferase NSUN4 between cysteines 358 and 378. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
4fp9
Structure name
human mterf4-nsun4 protein complex
Structure deposition date
2012-06-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
13
% buried
86
Peptide accession
Q96CB9
Residue number A
358
Residue number B
378
Peptide name
5-methylcytosine rRNA methyltransferase NSUN4

Ligandability

Cysteine 358 of 5-methylcytosine rRNA methyltransferase NSUN4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 378 of 5-methylcytosine rRNA methyltransferase NSUN4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 5-methylcytosine rRNA methyltransferase NSUN4 between cysteines 181 and 258. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
22
PDB code
7of0
Structure name
structure of a human mitochondrial ribosome large subunit assembly intermediate in complex with mterf4-nsun4 (dataset1)
Structure deposition date
2021-05-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
87
Minimum pKa ?
14
% buried
96
Peptide accession
Q96CB9
Residue number A
181
Residue number B
258
Peptide name
5-methylcytosine rRNA methyltransferase NSUN4

Ligandability

Cysteine 181 of 5-methylcytosine rRNA methyltransferase NSUN4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 258 of 5-methylcytosine rRNA methyltransferase NSUN4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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