HAUS augmin-like complex subunit 1

Intermolecular

Cysteine 156 and cysteine 511 of HAUS augmin-like complex subunit 3 L

Cysteine 156 and cysteine 241 of HAUS augmin-like complex subunit 4 L

A redox-regulated disulphide may form between cysteine 156 of HAUS augmin-like complex subunit 1 and cysteine 511 of HAUS augmin-like complex subunit 3. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7sqk

Structure name

cryo-em structure of the human augmin complex

Structure deposition date

2021-11-05

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

HAUS augmin-like complex subunit 1

Peptide B name

HAUS augmin-like complex subunit 3

Peptide A accession

Q96CS2

Peptide B accession

Q68CZ6

Peptide A residue number

156

Peptide B residue number

511

Ligandability

Cysteine 156 of HAUS augmin-like complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 511 of HAUS augmin-like complex subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 156 of HAUS augmin-like complex subunit 1 and cysteine 241 of HAUS augmin-like complex subunit 4 (156 and 196 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?