ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

BTB/POZ domain-containing protein KCTD12

Intermolecular
Cysteine 300 and cysteine 300
Cysteine 294 and cysteine 294
A redox-regulated disulphide may form between two units of BTB/POZ domain-containing protein KCTD12 at cysteines 300 and 300.

Details

Redox score ?
75
PDB code
6m8s
Structure name
crystal structure of the kctd12 h1 domain in complex with gbeta1gamma2 subunits
Structure deposition date
2018-08-22
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
24
Peptide A name
BTB/POZ domain-containing protein KCTD12
Peptide B name
BTB/POZ domain-containing protein KCTD12
Peptide A accession
Q96CX2
Peptide B accession
Q96CX2
Peptide A residue number
300
Peptide B residue number
300

Ligandability

A redox-regulated disulphide may form between two units of BTB/POZ domain-containing protein KCTD12 at cysteines 294 and 294. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6qzl
Structure name
structure of the h1 domain of human kctd12
Structure deposition date
2019-03-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
84
Minimum pKa ?
13
% buried
100
Peptide A name
BTB/POZ domain-containing protein KCTD12
Peptide B name
BTB/POZ domain-containing protein KCTD12
Peptide A accession
Q96CX2
Peptide B accession
Q96CX2
Peptide A residue number
294
Peptide B residue number
294

Ligandability

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