a tool for identifying drug-targetable redox-active disulphides

Enoyl-CoA hydratase domain-containing protein 3, mitochondrial

Intramolecular

Cysteine 155 and cysteine 183

A redox-regulated disulphide may form within Enoyl-CoA hydratase domain-containing protein 3, mitochondrial between cysteines 155 and 183. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

35

PDB code

Structure name

crystal structure of human enoyl coenzyme a hydratase domain-containing protein 3 (echdc3)

Structure deposition date

2008-06-30

Thiol separation (Å)

8

Half-sphere exposure sum ?

101

Minimum pK_a ?

12

% buried

100

Peptide accession

Residue number A

155

Residue number B

183

Peptide name

Enoyl-CoA hydratase domain-containing protein 3, mitochondrial

Ligandability

Cysteine 155 of Enoyl-CoA hydratase domain-containing protein 3, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of Enoyl-CoA hydratase domain-containing protein 3, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: