ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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SLAM family member 6

Intramolecular
Cysteine 147 and cysteine 214
Cysteine 153 and cysteine 195
A redox-regulated disulphide may form within SLAM family member 6 between cysteines 147 and 214 (125 and 192 respectively in this structure).

Details

Redox score ?
87
PDB code
2if7
Structure name
crystal structure of ntb-a
Structure deposition date
2006-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96DU3
Residue number A
147
Residue number B
214
Peptide name
SLAM family member 6

Ligandability

Cysteine 147 of SLAM family member 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 214 of SLAM family member 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within SLAM family member 6 between cysteines 153 and 195 (131 and 173 respectively in this structure).

Details

Redox score ?
83
PDB code
2if7
Structure name
crystal structure of ntb-a
Structure deposition date
2006-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96DU3
Residue number A
153
Residue number B
195
Peptide name
SLAM family member 6

Ligandability

Cysteine 153 of SLAM family member 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 of SLAM family member 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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