a tool for identifying drug-targetable redox-active disulphides

Inositol-trisphosphate 3-kinase C

Intramolecular

Cysteine 434 and cysteine 436 L

A redox-regulated disulphide may form within Inositol-trisphosphate 3-kinase C between cysteines 434 and 436.

Details

Redox score ?

62

PDB code

Structure name

crystal structure of the catalytic domain of human inositol 1,4,5- trisphosphate 3-kinase c

Structure deposition date

2005-07-11

Thiol separation (Å)

6

Half-sphere exposure sum ?

45

Minimum pK_a ?

9

% buried

38

Peptide accession

Residue number A

434

Residue number B

436

Peptide name

Inositol-trisphosphate 3-kinase C

Ligandability

Cysteine 434 of Inositol-trisphosphate 3-kinase C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 436 of Inositol-trisphosphate 3-kinase C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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