Ankyrin repeat and SOCS box protein 9
Intermolecular
Cysteine 262 and cysteine 112 of Elongin-C
Intramolecular
Cysteine 110 and cysteine 149
Cysteine 77 and cysteine 117
Cysteine 117 and cysteine 149
Cysteine 84 and cysteine 117
Cysteine 175 and cysteine 182
Cysteine 149 and cysteine 182
Cysteine 77 and cysteine 110
3zkj A 262 B 112
A redox-regulated disulphide may form between cysteine 262 of Ankyrin repeat and SOCS box protein 9 and cysteine 112 of Elongin-C. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
3zkj
Structure name
crystal structure of ankyrin repeat and socs box-containing protein 9 (asb9) in complex with elonginb and elonginc
Structure deposition date
2013-01-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
13
% buried
88
Peptide A name
Ankyrin repeat and SOCS box protein 9
Peptide B name
Elongin-C
Peptide A accession
Q96DX5
Peptide B accession
Q15369
Peptide A residue number
262
Peptide B residue number
112
Ligandability
Cysteine 262 of Ankyrin repeat and SOCS box protein 9
Cysteine 112 of Elongin-C
3d9h A 110 A 149
A redox-regulated disulphide may form within Ankyrin repeat and SOCS box protein 9 between cysteines 110 and 149.
Details
Redox score ?
66
PDB code
3d9h
Structure name
crystal structure of the splice variant of human asb9 (hasb9-2), an ankyrin repeat protein
Structure deposition date
2008-05-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
83
Minimum pKa ?
8
% buried
83
Peptide accession
A8K8A5
Residue number A
110
Residue number B
149
Peptide name
Ankyrin repeat and SOCS box protein 9
Ligandability
Cysteine 110 of Ankyrin repeat and SOCS box protein 9
Cysteine 149 of Ankyrin repeat and SOCS box protein 9
3d9h A 77 A 117
A redox-regulated disulphide may form within Ankyrin repeat and SOCS box protein 9 between cysteines 77 and 117. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
3d9h
Structure name
crystal structure of the splice variant of human asb9 (hasb9-2), an ankyrin repeat protein
Structure deposition date
2008-05-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
84
Minimum pKa ?
11
% buried
82
Peptide accession
A8K8A5
Residue number A
77
Residue number B
117
Peptide name
Ankyrin repeat and SOCS box protein 9
Ligandability
Cysteine 77 of Ankyrin repeat and SOCS box protein 9
Cysteine 117 of Ankyrin repeat and SOCS box protein 9
3d9h A 117 A 149
A redox-regulated disulphide may form within Ankyrin repeat and SOCS box protein 9 between cysteines 117 and 149. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
3d9h
Structure name
crystal structure of the splice variant of human asb9 (hasb9-2), an ankyrin repeat protein
Structure deposition date
2008-05-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
8
% buried
64
Peptide accession
A8K8A5
Residue number A
117
Residue number B
149
Peptide name
Ankyrin repeat and SOCS box protein 9
Ligandability
Cysteine 117 of Ankyrin repeat and SOCS box protein 9
Cysteine 149 of Ankyrin repeat and SOCS box protein 9
6v9h C 84 C 117
A redox-regulated disulphide may form within Ankyrin repeat and SOCS box protein 9 between cysteines 84 and 117. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
6v9h
Structure name
ankyrin repeat and socs-box protein 9 (asb9), elonginb (elob), and elonginc (eloc) bound to its substrate brain-type creatine kinase (ckb)
Structure deposition date
2019-12-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
80
Peptide accession
Q96DX5
Residue number A
84
Residue number B
117
Peptide name
Ankyrin repeat and SOCS box protein 9
Ligandability
Cysteine 84 of Ankyrin repeat and SOCS box protein 9
Cysteine 117 of Ankyrin repeat and SOCS box protein 9
6v9h C 175 C 182
A redox-regulated disulphide may form within Ankyrin repeat and SOCS box protein 9 between cysteines 175 and 182. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
6v9h
Structure name
ankyrin repeat and socs-box protein 9 (asb9), elonginb (elob), and elonginc (eloc) bound to its substrate brain-type creatine kinase (ckb)
Structure deposition date
2019-12-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
84
Peptide accession
Q96DX5
Residue number A
175
Residue number B
182
Peptide name
Ankyrin repeat and SOCS box protein 9
Ligandability
Cysteine 175 of Ankyrin repeat and SOCS box protein 9
Cysteine 182 of Ankyrin repeat and SOCS box protein 9
6v9h C 149 C 182
A redox-regulated disulphide may form within Ankyrin repeat and SOCS box protein 9 between cysteines 149 and 182. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
6v9h
Structure name
ankyrin repeat and socs-box protein 9 (asb9), elonginb (elob), and elonginc (eloc) bound to its substrate brain-type creatine kinase (ckb)
Structure deposition date
2019-12-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
64
Peptide accession
Q96DX5
Residue number A
149
Residue number B
182
Peptide name
Ankyrin repeat and SOCS box protein 9
Ligandability
Cysteine 149 of Ankyrin repeat and SOCS box protein 9
Cysteine 182 of Ankyrin repeat and SOCS box protein 9
6v9h C 77 C 110
A redox-regulated disulphide may form within Ankyrin repeat and SOCS box protein 9 between cysteines 77 and 110. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
6v9h
Structure name
ankyrin repeat and socs-box protein 9 (asb9), elonginb (elob), and elonginc (eloc) bound to its substrate brain-type creatine kinase (ckb)
Structure deposition date
2019-12-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
92
Minimum pKa ?
13
% buried
100
Peptide accession
Q96DX5
Residue number A
77
Residue number B
110
Peptide name
Ankyrin repeat and SOCS box protein 9
Ligandability
Cysteine 77 of Ankyrin repeat and SOCS box protein 9
Cysteine 110 of Ankyrin repeat and SOCS box protein 9
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