a tool for identifying drug-targetable redox-active disulphides

Dehydrodolichyl diphosphate synthase complex subunit NUS1

Intermolecular

Cysteine 191 of Dehydrodolichyl diphosphate synthase complex subunit DHDDS and cysteine 208

A redox-regulated disulphide may form between cysteine 191 of Dehydrodolichyl diphosphate synthase complex subunit DHDDS and cysteine 208 of Dehydrodolichyl diphosphate synthase complex subunit NUS1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

32

PDB code

Structure name

structure of the human heterotetrameric cis-prenyltransferase complex

Structure deposition date

2020-05-14

Thiol separation (Å)

9

Half-sphere exposure sum ?

77

Minimum pK_a ?

12

% buried

93

Peptide A name

Dehydrodolichyl diphosphate synthase complex subunit DHDDS

Peptide B name

Dehydrodolichyl diphosphate synthase complex subunit NUS1

Peptide A accession

Peptide B accession

Peptide A residue number

191

Peptide B residue number

208

Ligandability

Cysteine 191 of Dehydrodolichyl diphosphate synthase complex subunit DHDDS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of Dehydrodolichyl diphosphate synthase complex subunit NUS1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: