ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Killer cell lectin-like receptor subfamily G member 1

Intermolecular
Cysteine 75 and cysteine 75
Intramolecular
Cysteine 75 and cysteine 86
Cysteine 103 and cysteine 184
Cysteine 163 and cysteine 176
Cysteine 75 and cysteine 86
Cysteine 86 and cysteine 183
A redox-regulated disulphide may form between two units of Killer cell lectin-like receptor subfamily G member 1 at cysteines 75 and 75. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
3ff8
Structure name
structure of nk cell receptor klrg1 bound to e-cadherin
Structure deposition date
2008-12-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Killer cell lectin-like receptor subfamily G member 1
Peptide B name
Killer cell lectin-like receptor subfamily G member 1
Peptide A accession
O88713
Peptide B accession
O88713
Peptide A residue number
75
Peptide B residue number
75

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Killer cell lectin-like receptor subfamily G member 1 between cysteines 75 and 86.

Details

Redox score ?
88
PDB code
3ff7
Structure name
structure of nk cell receptor klrg1 bound to e-cadherin
Structure deposition date
2008-12-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96E93
Residue number A
75
Residue number B
86
Peptide name
Killer cell lectin-like receptor subfamily G member 1

Ligandability

Cysteine 75 of Killer cell lectin-like receptor subfamily G member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 86 of Killer cell lectin-like receptor subfamily G member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Killer cell lectin-like receptor subfamily G member 1 between cysteines 103 and 184.

Details

Redox score ?
82
PDB code
3ff7
Structure name
structure of nk cell receptor klrg1 bound to e-cadherin
Structure deposition date
2008-12-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96E93
Residue number A
103
Residue number B
184
Peptide name
Killer cell lectin-like receptor subfamily G member 1

Ligandability

Cysteine 103 of Killer cell lectin-like receptor subfamily G member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 184 of Killer cell lectin-like receptor subfamily G member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Killer cell lectin-like receptor subfamily G member 1 between cysteines 163 and 176.

Details

Redox score ?
79
PDB code
3ff7
Structure name
structure of nk cell receptor klrg1 bound to e-cadherin
Structure deposition date
2008-12-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96E93
Residue number A
163
Residue number B
176
Peptide name
Killer cell lectin-like receptor subfamily G member 1

Ligandability

Cysteine 163 of Killer cell lectin-like receptor subfamily G member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 176 of Killer cell lectin-like receptor subfamily G member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Killer cell lectin-like receptor subfamily G member 1 between cysteines 75 and 86.

Details

Redox score ?
79
PDB code
3ff8
Structure name
structure of nk cell receptor klrg1 bound to e-cadherin
Structure deposition date
2008-12-02
Thiol separation (Å)
3
Half-sphere exposure sum ?
nan
Minimum pKa ?
11
% buried
nan
Peptide accession
O88713
Residue number A
75
Residue number B
86
Peptide name
Killer cell lectin-like receptor subfamily G member 1

Ligandability

Cysteine 75 of Killer cell lectin-like receptor subfamily G member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 86 of Killer cell lectin-like receptor subfamily G member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Killer cell lectin-like receptor subfamily G member 1 between cysteines 86 and 183 (86 and 184 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
3ff8
Structure name
structure of nk cell receptor klrg1 bound to e-cadherin
Structure deposition date
2008-12-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
nan
Peptide accession
O88713
Residue number A
86
Residue number B
183
Peptide name
Killer cell lectin-like receptor subfamily G member 1

Ligandability

Cysteine 86 of Killer cell lectin-like receptor subfamily G member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of Killer cell lectin-like receptor subfamily G member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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