ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein Spindly

Intermolecular
Cysteine 44 and cysteine 44
Cysteine 80 and cysteine 80
Cysteine 78 and cysteine 80
A redox-regulated disulphide may form between two units of Protein Spindly at cysteines 44 and 44.

Details

Redox score ?
84
PDB code
8arf
Structure name
crystal structure of the n-terminal parallel dimeric coiled-coil region of the human kinetochore associated protein spindly
Structure deposition date
2022-08-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide A name
Protein Spindly
Peptide B name
Protein Spindly
Peptide A accession
Q96EA4
Peptide B accession
Q96EA4
Peptide A residue number
44
Peptide B residue number
44

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Protein Spindly at cysteines 80 and 80.

Details

Redox score ?
83
PDB code
8arf
Structure name
crystal structure of the n-terminal parallel dimeric coiled-coil region of the human kinetochore associated protein spindly
Structure deposition date
2022-08-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide A name
Protein Spindly
Peptide B name
Protein Spindly
Peptide A accession
Q96EA4
Peptide B accession
Q96EA4
Peptide A residue number
80
Peptide B residue number
80

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Protein Spindly at cysteines 78 and 80. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
8arf
Structure name
crystal structure of the n-terminal parallel dimeric coiled-coil region of the human kinetochore associated protein spindly
Structure deposition date
2022-08-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
44
Minimum pKa ?
10
% buried
nan
Peptide A name
Protein Spindly
Peptide B name
Protein Spindly
Peptide A accession
Q96EA4
Peptide B accession
Q96EA4
Peptide A residue number
78
Peptide B residue number
80

Ligandability

Cysteine 78 of Protein Spindly

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 80 of Protein Spindly

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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