ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Pentatricopeptide repeat domain-containing protein 3, mitochondrial

Intramolecular
Cysteine 303 and cysteine 341
Cysteine 196 and cysteine 260
A redox-regulated disulphide may form within Pentatricopeptide repeat domain-containing protein 3, mitochondrial between cysteines 303 and 341. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
8csu
Structure name
human mitochondrial small subunit assembly intermediate (state c*)
Structure deposition date
2022-05-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
72
Peptide accession
Q96EY7
Residue number A
303
Residue number B
341
Peptide name
Pentatricopeptide repeat domain-containing protein 3, mitochondrial

Ligandability

Cysteine 303 of Pentatricopeptide repeat domain-containing protein 3, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 341 of Pentatricopeptide repeat domain-containing protein 3, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pentatricopeptide repeat domain-containing protein 3, mitochondrial between cysteines 196 and 260. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
8csq
Structure name
human mitochondrial small subunit assembly intermediate (state b)
Structure deposition date
2022-05-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
89
Peptide accession
Q96EY7
Residue number A
196
Residue number B
260
Peptide name
Pentatricopeptide repeat domain-containing protein 3, mitochondrial

Ligandability

Cysteine 196 of Pentatricopeptide repeat domain-containing protein 3, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 260 of Pentatricopeptide repeat domain-containing protein 3, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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