ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Probable inactive tRNA-specific adenosine deaminase-like protein 3

Intramolecular
Cysteine 289 and cysteine 292
Cysteine 214 and cysteine 228
Cysteine 228 and cysteine 277
Cysteine 228 and cysteine 292
A redox-regulated disulphide may form within Probable inactive tRNA-specific adenosine deaminase-like protein 3 between cysteines 289 and 292.

Details

Redox score ?
74
PDB code
7nz8
Structure name
crystal structure of mouse adat2/adat3 trna deamination complex 2
Structure deposition date
2021-03-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
93
Minimum pKa ?
4
% buried
100
Peptide accession
Q6PAT0
Residue number A
289
Residue number B
292
Peptide name
Probable inactive tRNA-specific adenosine deaminase-like protein 3

Ligandability

Cysteine 289 of Probable inactive tRNA-specific adenosine deaminase-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 292 of Probable inactive tRNA-specific adenosine deaminase-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Probable inactive tRNA-specific adenosine deaminase-like protein 3 between cysteines 214 and 228. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7nz8
Structure name
crystal structure of mouse adat2/adat3 trna deamination complex 2
Structure deposition date
2021-03-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
62
Peptide accession
Q6PAT0
Residue number A
214
Residue number B
228
Peptide name
Probable inactive tRNA-specific adenosine deaminase-like protein 3

Ligandability

Cysteine 214 of Probable inactive tRNA-specific adenosine deaminase-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 228 of Probable inactive tRNA-specific adenosine deaminase-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Probable inactive tRNA-specific adenosine deaminase-like protein 3 between cysteines 228 and 277. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
7nz9
Structure name
crystal structure of mouse adat2/adat3 trna deamination complex v128l mutant
Structure deposition date
2021-03-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
100
Peptide accession
Q6PAT0
Residue number A
228
Residue number B
277
Peptide name
Probable inactive tRNA-specific adenosine deaminase-like protein 3

Ligandability

Cysteine 228 of Probable inactive tRNA-specific adenosine deaminase-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 277 of Probable inactive tRNA-specific adenosine deaminase-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Probable inactive tRNA-specific adenosine deaminase-like protein 3 between cysteines 228 and 292. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
24
PDB code
7nz9
Structure name
crystal structure of mouse adat2/adat3 trna deamination complex v128l mutant
Structure deposition date
2021-03-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
100
Peptide accession
Q6PAT0
Residue number A
228
Residue number B
292
Peptide name
Probable inactive tRNA-specific adenosine deaminase-like protein 3

Ligandability

Cysteine 228 of Probable inactive tRNA-specific adenosine deaminase-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 292 of Probable inactive tRNA-specific adenosine deaminase-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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