Interleukin-17 receptor A
Intramolecular
Cysteine 43 and cysteine 50
Cysteine 277 and cysteine 303
Cysteine 185 and cysteine 196
Cysteine 245 and cysteine 276
Cysteine 57 and cysteine 126
Cysteine 290 and cysteine 294
Cysteine 581 and cysteine 587
Cysteine 276 and cysteine 303
Cysteine 276 and cysteine 277
Cysteine 185 and cysteine 294
More...Cysteine 245 and cysteine 277
Cysteine 245 and cysteine 303
Cysteine 185 and cysteine 290
Cysteine 196 and cysteine 290
Cysteine 447 and cysteine 502
5nan B 43 B 50
A redox-regulated disulphide may form within Interleukin-17 receptor A between cysteines 43 and 50.
Details
Redox score ?
87
PDB code
5nan
Structure name
crystal structure of human il-17af in complex with human il-17ra
Structure deposition date
2017-02-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96F46
Residue number A
43
Residue number B
50
Peptide name
Interleukin-17 receptor A
Ligandability
Cysteine 43 of Interleukin-17 receptor A
Cysteine 50 of Interleukin-17 receptor A
5n9b A 277 A 303
A redox-regulated disulphide may form within Interleukin-17 receptor A between cysteines 277 and 303.
Details
Redox score ?
85
PDB code
5n9b
Structure name
crystal structure of unliganded human il-17ra
Structure deposition date
2017-02-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96F46
Residue number A
277
Residue number B
303
Peptide name
Interleukin-17 receptor A
Ligandability
Cysteine 277 of Interleukin-17 receptor A
Cysteine 303 of Interleukin-17 receptor A
5nan B 185 B 196
A redox-regulated disulphide may form within Interleukin-17 receptor A between cysteines 185 and 196.
Details
Redox score ?
85
PDB code
5nan
Structure name
crystal structure of human il-17af in complex with human il-17ra
Structure deposition date
2017-02-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96F46
Residue number A
185
Residue number B
196
Peptide name
Interleukin-17 receptor A
Ligandability
Cysteine 185 of Interleukin-17 receptor A
Cysteine 196 of Interleukin-17 receptor A
5n9b A 245 A 276
A redox-regulated disulphide may form within Interleukin-17 receptor A between cysteines 245 and 276.
Details
Redox score ?
84
PDB code
5n9b
Structure name
crystal structure of unliganded human il-17ra
Structure deposition date
2017-02-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96F46
Residue number A
245
Residue number B
276
Peptide name
Interleukin-17 receptor A
Ligandability
Cysteine 245 of Interleukin-17 receptor A
Cysteine 276 of Interleukin-17 receptor A
3jvf C 26 C 95
A redox-regulated disulphide may form within Interleukin-17 receptor A between cysteines 57 and 126 (26 and 95 respectively in this structure).
Details
Redox score ?
84
PDB code
3jvf
Structure name
crystal structure of an interleukin-17 receptor complex
Structure deposition date
2009-09-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96F46
Residue number A
57
Residue number B
126
Peptide name
Interleukin-17 receptor A
Ligandability
Cysteine 57 of Interleukin-17 receptor A
Cysteine 126 of Interleukin-17 receptor A
4hsa F 259 F 263
A redox-regulated disulphide may form within Interleukin-17 receptor A between cysteines 290 and 294 (259 and 263 respectively in this structure).
Details
Redox score ?
84
PDB code
4hsa
Structure name
structure of interleukin 17a in complex with il17ra receptor
Structure deposition date
2012-10-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96F46
Residue number A
290
Residue number B
294
Peptide name
Interleukin-17 receptor A
Ligandability
Cysteine 290 of Interleukin-17 receptor A
Cysteine 294 of Interleukin-17 receptor A
4nux A 581 A 587
A redox-regulated disulphide may form within Interleukin-17 receptor A between cysteines 581 and 587.
Details
Redox score ?
72
PDB code
4nux
Structure name
structure of receptor a
Structure deposition date
2013-12-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
33
Minimum pKa ?
9
% buried
0
Peptide accession
Q96F46
Residue number A
581
Residue number B
587
Peptide name
Interleukin-17 receptor A
Ligandability
Cysteine 581 of Interleukin-17 receptor A
Cysteine 587 of Interleukin-17 receptor A
4hsa F 245 F 272
A redox-regulated disulphide may form within Interleukin-17 receptor A between cysteines 276 and 303 (245 and 272 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
4hsa
Structure name
structure of interleukin 17a in complex with il17ra receptor
Structure deposition date
2012-10-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96F46
Residue number A
276
Residue number B
303
Peptide name
Interleukin-17 receptor A
Ligandability
Cysteine 276 of Interleukin-17 receptor A
Cysteine 303 of Interleukin-17 receptor A
5n9b A 276 A 277
A redox-regulated disulphide may form within Interleukin-17 receptor A between cysteines 276 and 277. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
5n9b
Structure name
crystal structure of unliganded human il-17ra
Structure deposition date
2017-02-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96F46
Residue number A
276
Residue number B
277
Peptide name
Interleukin-17 receptor A
Ligandability
Cysteine 276 of Interleukin-17 receptor A
Cysteine 277 of Interleukin-17 receptor A
7uwn F 185 F 294
A redox-regulated disulphide may form within Interleukin-17 receptor A between cysteines 185 and 294. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7uwn
Structure name
structure of the il-17a-il-17ra-il-17rc ternary complex
Structure deposition date
2022-05-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96F46
Residue number A
185
Residue number B
294
Peptide name
Interleukin-17 receptor A
Ligandability
Cysteine 185 of Interleukin-17 receptor A
Cysteine 294 of Interleukin-17 receptor A
3jvf C 214 C 246
A redox-regulated disulphide may form within Interleukin-17 receptor A between cysteines 245 and 277 (214 and 246 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
3jvf
Structure name
crystal structure of an interleukin-17 receptor complex
Structure deposition date
2009-09-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
nan
Peptide accession
Q96F46
Residue number A
245
Residue number B
277
Peptide name
Interleukin-17 receptor A
Ligandability
Cysteine 245 of Interleukin-17 receptor A
Cysteine 277 of Interleukin-17 receptor A
5nan B 245 B 303
A redox-regulated disulphide may form within Interleukin-17 receptor A between cysteines 245 and 303. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
5nan
Structure name
crystal structure of human il-17af in complex with human il-17ra
Structure deposition date
2017-02-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96F46
Residue number A
245
Residue number B
303
Peptide name
Interleukin-17 receptor A
Ligandability
Cysteine 245 of Interleukin-17 receptor A
Cysteine 303 of Interleukin-17 receptor A
4hsa F 154 F 259
A redox-regulated disulphide may form within Interleukin-17 receptor A between cysteines 185 and 290 (154 and 259 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
4hsa
Structure name
structure of interleukin 17a in complex with il17ra receptor
Structure deposition date
2012-10-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96F46
Residue number A
185
Residue number B
290
Peptide name
Interleukin-17 receptor A
Ligandability
Cysteine 185 of Interleukin-17 receptor A
Cysteine 290 of Interleukin-17 receptor A
7uwn F 196 F 290
A redox-regulated disulphide may form within Interleukin-17 receptor A between cysteines 196 and 290. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7uwn
Structure name
structure of the il-17a-il-17ra-il-17rc ternary complex
Structure deposition date
2022-05-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96F46
Residue number A
196
Residue number B
290
Peptide name
Interleukin-17 receptor A
Ligandability
Cysteine 196 of Interleukin-17 receptor A
Cysteine 290 of Interleukin-17 receptor A
4nux A 447 A 502
A redox-regulated disulphide may form within Interleukin-17 receptor A between cysteines 447 and 502. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
4nux
Structure name
structure of receptor a
Structure deposition date
2013-12-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
13
% buried
100
Peptide accession
Q96F46
Residue number A
447
Residue number B
502
Peptide name
Interleukin-17 receptor A
Ligandability
Cysteine 447 of Interleukin-17 receptor A
Cysteine 502 of Interleukin-17 receptor A
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