ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Enhancer of mRNA-decapping protein 3

Intermolecular
Cysteine 311 and cysteine 311
Intramolecular
Cysteine 311 and cysteine 477
Cysteine 341 and cysteine 410
Cysteine 353 and cysteine 410
Cysteine 341 and cysteine 353
Cysteine 353 and cysteine 477
A redox-regulated disulphide may form between two units of Enhancer of mRNA-decapping protein 3 at cysteines 311 and 311. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
3d3k
Structure name
crystal structure of human edc3p
Structure deposition date
2008-05-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
86
Minimum pKa ?
9
% buried
100
Peptide A name
Enhancer of mRNA-decapping protein 3
Peptide B name
Enhancer of mRNA-decapping protein 3
Peptide A accession
Q96F86
Peptide B accession
Q96F86
Peptide A residue number
311
Peptide B residue number
311

Ligandability

A redox-regulated disulphide may form within Enhancer of mRNA-decapping protein 3 between cysteines 311 and 477.

Details

Redox score ?
68
PDB code
3d3k
Structure name
crystal structure of human edc3p
Structure deposition date
2008-05-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
7
% buried
72
Peptide accession
Q96F86
Residue number A
311
Residue number B
477
Peptide name
Enhancer of mRNA-decapping protein 3

Ligandability

Cysteine 311 of Enhancer of mRNA-decapping protein 3

Cysteine 477 of Enhancer of mRNA-decapping protein 3

A redox-regulated disulphide may form within Enhancer of mRNA-decapping protein 3 between cysteines 341 and 410. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
3d3k
Structure name
crystal structure of human edc3p
Structure deposition date
2008-05-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
89
Minimum pKa ?
9
% buried
100
Peptide accession
Q96F86
Residue number A
341
Residue number B
410
Peptide name
Enhancer of mRNA-decapping protein 3

Ligandability

Cysteine 341 of Enhancer of mRNA-decapping protein 3

Cysteine 410 of Enhancer of mRNA-decapping protein 3

A redox-regulated disulphide may form within Enhancer of mRNA-decapping protein 3 between cysteines 353 and 410. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3d3k
Structure name
crystal structure of human edc3p
Structure deposition date
2008-05-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
92
Minimum pKa ?
9
% buried
100
Peptide accession
Q96F86
Residue number A
353
Residue number B
410
Peptide name
Enhancer of mRNA-decapping protein 3

Ligandability

Cysteine 353 of Enhancer of mRNA-decapping protein 3

Cysteine 410 of Enhancer of mRNA-decapping protein 3

A redox-regulated disulphide may form within Enhancer of mRNA-decapping protein 3 between cysteines 341 and 353. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
3d3k
Structure name
crystal structure of human edc3p
Structure deposition date
2008-05-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
94
Minimum pKa ?
13
% buried
100
Peptide accession
Q96F86
Residue number A
341
Residue number B
353
Peptide name
Enhancer of mRNA-decapping protein 3

Ligandability

Cysteine 341 of Enhancer of mRNA-decapping protein 3

Cysteine 353 of Enhancer of mRNA-decapping protein 3

A redox-regulated disulphide may form within Enhancer of mRNA-decapping protein 3 between cysteines 353 and 477. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
22
PDB code
3d3k
Structure name
crystal structure of human edc3p
Structure deposition date
2008-05-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
13
% buried
100
Peptide accession
Q96F86
Residue number A
353
Residue number B
477
Peptide name
Enhancer of mRNA-decapping protein 3

Ligandability

Cysteine 353 of Enhancer of mRNA-decapping protein 3

Cysteine 477 of Enhancer of mRNA-decapping protein 3

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