Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Intramolecular
Cysteine 42 and cysteine 48
Cysteine 46 and cysteine 57
Cysteine 375 and cysteine 421
Cysteine 373 and cysteine 396
Cysteine 446 and cysteine 497
Cysteine 46 and cysteine 48
Cysteine 42 and cysteine 46
Cysteine 48 and cysteine 57
Cysteine 42 and cysteine 57
2id5 A 3 A 9
A redox-regulated disulphide may form within Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 between cysteines 42 and 48 (3 and 9 respectively in this structure).
Details
Redox score ?
89
PDB code
2id5
Structure name
crystal structure of the lingo-1 ectodomain
Structure deposition date
2006-09-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96FE5
Residue number A
42
Residue number B
48
Peptide name
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Ligandability
Cysteine 42 of Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Cysteine 48 of Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
2id5 B 7 B 18
A redox-regulated disulphide may form within Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 between cysteines 46 and 57 (7 and 18 respectively in this structure).
Details
Redox score ?
85
PDB code
2id5
Structure name
crystal structure of the lingo-1 ectodomain
Structure deposition date
2006-09-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96FE5
Residue number A
46
Residue number B
57
Peptide name
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Ligandability
Cysteine 46 of Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Cysteine 57 of Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
2id5 C 336 C 382
A redox-regulated disulphide may form within Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 between cysteines 375 and 421 (336 and 382 respectively in this structure).
Details
Redox score ?
84
PDB code
2id5
Structure name
crystal structure of the lingo-1 ectodomain
Structure deposition date
2006-09-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96FE5
Residue number A
375
Residue number B
421
Peptide name
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Ligandability
Cysteine 375 of Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Cysteine 421 of Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
4oqt A 334 A 357
A redox-regulated disulphide may form within Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 between cysteines 373 and 396 (334 and 357 respectively in this structure).
Details
Redox score ?
82
PDB code
4oqt
Structure name
lingo-1/li81 fab complex
Structure deposition date
2014-02-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96FE5
Residue number A
373
Residue number B
396
Peptide name
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Ligandability
Cysteine 373 of Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Cysteine 396 of Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
2id5 D 407 D 458
A redox-regulated disulphide may form within Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 between cysteines 446 and 497 (407 and 458 respectively in this structure).
Details
Redox score ?
81
PDB code
2id5
Structure name
crystal structure of the lingo-1 ectodomain
Structure deposition date
2006-09-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96FE5
Residue number A
446
Residue number B
497
Peptide name
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Ligandability
Cysteine 446 of Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Cysteine 497 of Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
4oqt A 7 A 9
A redox-regulated disulphide may form within Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 between cysteines 46 and 48 (7 and 9 respectively in this structure).
Details
Redox score ?
70
PDB code
4oqt
Structure name
lingo-1/li81 fab complex
Structure deposition date
2014-02-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96FE5
Residue number A
46
Residue number B
48
Peptide name
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Ligandability
Cysteine 46 of Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Cysteine 48 of Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
2id5 B 3 B 7
A redox-regulated disulphide may form within Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 between cysteines 42 and 46 (3 and 7 respectively in this structure).
Details
Redox score ?
67
PDB code
2id5
Structure name
crystal structure of the lingo-1 ectodomain
Structure deposition date
2006-09-14
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96FE5
Residue number A
42
Residue number B
46
Peptide name
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Ligandability
Cysteine 42 of Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Cysteine 46 of Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
4oqt A 9 A 18
A redox-regulated disulphide may form within Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 between cysteines 48 and 57 (9 and 18 respectively in this structure).
Details
Redox score ?
63
PDB code
4oqt
Structure name
lingo-1/li81 fab complex
Structure deposition date
2014-02-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96FE5
Residue number A
48
Residue number B
57
Peptide name
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Ligandability
Cysteine 48 of Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Cysteine 57 of Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
4oqt A 3 A 18
A redox-regulated disulphide may form within Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 between cysteines 42 and 57 (3 and 18 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
4oqt
Structure name
lingo-1/li81 fab complex
Structure deposition date
2014-02-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96FE5
Residue number A
42
Residue number B
57
Peptide name
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Ligandability
Cysteine 42 of Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Cysteine 57 of Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
If this tool was useful for finding a disulphide, please cite: