a tool for identifying drug-targetable redox-active disulphides

Seipin

Intramolecular

Cysteine 74 and cysteine 82

A redox-regulated disulphide may form within Seipin between cysteines 74 and 82.

Details

Redox score ?

84

PDB code

Structure name

cryo em structure of human seipin

Structure deposition date

2018-06-13

Thiol separation (Å)

2

Half-sphere exposure sum ?

43

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

74

Residue number B

82

Peptide name

Seipin

Ligandability

Cysteine 74 of Seipin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 82 of Seipin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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