ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Polycomb protein SCMH1

Intramolecular
Cysteine 76 and cysteine 116
Cysteine 185 and cysteine 225
A redox-regulated disulphide may form within Polycomb protein SCMH1 between cysteines 76 and 116. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2p0k
Structure name
crystal structure of scmh1
Structure deposition date
2007-02-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
35
Peptide accession
Q96GD3
Residue number A
76
Residue number B
116
Peptide name
Polycomb protein SCMH1

Ligandability

Cysteine 76 of Polycomb protein SCMH1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 116 of Polycomb protein SCMH1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polycomb protein SCMH1 between cysteines 185 and 225. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
2p0k
Structure name
crystal structure of scmh1
Structure deposition date
2007-02-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
66
Peptide accession
Q96GD3
Residue number A
185
Residue number B
225
Peptide name
Polycomb protein SCMH1

Ligandability

Cysteine 185 of Polycomb protein SCMH1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 225 of Polycomb protein SCMH1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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